|Present||Interim Chair, Philadelphia College of Osteopathic Medicine ‐ Department of Bio-Medical Sciences|
|Present||Professor of Physiology and Pharmacology, Philadelphia College of Osteopathic Medicine ‐ Department of Bio-Medical Sciences|
|Associate Director, Philadelphia College of Osteopathic Medicine ‐ Department of Bio-Medical Sciences|
|2010 - 2014||Protective activity of the lectin-like domain of TNF in permeability edema|
|NIH - HL094609|
|Colleague(s): R. Lucas (PI)|
|2007 - 2011||PKC Signaling in cAMP-induced pulmonary vasodilation|
|NIH - HL68026|
|Colleague(s): S.A. Barman (PI)|
|2006 - 2010||Nongenomic mechanisms of androgens in the vascular wall|
|NIH - HL080402|
|Colleague(s): J.N. Stallone (PI)|
|1997 - 2009||Role of icosanoids in renal function|
|NIH - NIDDK 2 PO1 DK38226-18|
|Colleague(s): H. Capdevila (Co-PI), J. Imig (Co-PI)|
|2006 - 2008||Estrogen dual effects on coronary arteries (Reentry supplement)|
|NIH - HL073890|
|Colleague(s): Mary P. Owen (Co-PI)|
|2004 - 2008||Estrogen dual effects on coronary arteries|
|NIH - HL073890|
|2001 - 2006||PKC signaling in cAMP-induced pulmonary vasodilation|
|Colleague(s): S. Barman (PI)|
|2000 - 2005||Molecular basis of cAMP-induced coronary vasorelaxation|
|NIH - HL64779|
|1999 - 2002||The molecular basis of estrogen action on human coronary artery smooth muscle|
|American Heart Association|
|1996 - 2001||Mechanisms of estrogen-induced coronary vasodilation|
|National Institutes of Health - HL54844|
|1995 - 1996||Female sex hormones prevent age-induced cardiovascular dysfunction|
|American Federation For Aging Research|
|1993 - 1994||Regulation of coronary artery ion channels by adenosine|
|National Heart Foundation/American Health Assistance Foundation|
Professional Service and Affiliations
|2002 - Present||Fellow, American Heart Association|
Honors and Awards
- Educator of Excellence Award, Georgia Campus-Philadelphia College of Osteopathic Medicine, 2014
- National Junior Investigator Achievement Award, National Heart Foundation, 1993
- Award for Excellence in Medical Teaching & Research, Wright State University School of Medicine, 1997
- Distinguished Graduate Teaching Award, Medical College of Georgia, 2004
- Who’s Who in Medical Sciences Education, 2005
- Master Lecturer, DeBakey Cardiovascular Research Institute, Texas A&M University, 2007
- IBC Leading Scientist of the World, 2007
- Distinguished Faculty Award for Basic Science Teaching, Medical College of Georgia, 2009
- Distinguished Alumnus Award, College of Graduate Studies, MCG-Georgia Regents University, 2011
|1987||PhD, Medical College of Georgia ‐ Pharmacology|
|1987||BS, Emory University ‐ Biology|
Scholarly Articles (52)
Peroxynitrite mediates testosterone-induced vasorelaxation of microvascular resistance vessels
Journal of Pharmacology and Experimental Therapeutics (2013)
Our knowledge of how androgens influence the cardiovascular system is far from complete, and this lack of understanding is especially ...
Agonist of growth hormone-releasing hormone reduces pneumolysin-induced pulmonary permeability edema
Proceedings of the National Academy of Sciences of the United States of America (2012)
Aggressive treatment with antibiotics in patients infected with Streptococcus pneumoniae induces release of the bacterial virulence factor pneumolysin (PLY). Days ...
Testosterone-induced relaxation of coronary arteries: Activation of Bk ca channels ...
American Journal of Physiology - Heart and Circulatory Physiology (2012)
Androgens are reported to have both beneficial and detrimental effects on human cardiovascular health. The aim of this study was ...
Activation of G protein-coupled estrogen receptor induces endotheliumindependent relaxation of ...
American Journal of Physiology - Endocrinology and Metabolism (2011)
Estrogens can either relax or contract arteries via rapid, nongenomic mechanisms involving classic estrogen receptors (ER). In addition to ERα ...
The role of N-methyl-D-aspartate receptor activation in homocysteine-induced death of ...
Investigative Ophthalmology and Visual Science (2011)
Purpose. Elevated plasma homocysteine has been implicated in glaucoma, a vision disorder characterized by retinal ganglion cell death. The toxic ...
The D5 dopamine receptor mediates large-conductance, calcium- and voltage-activated potassium ...
Journal of Pharmacology and Experimental Therapeutics (2010)
Large-conductance, calcium- and voltage-activated potassium (BK Ca) channels hyperpolarize coronary artery smooth muscle cells, causing vasorelaxation. Dopamine activates BKCa channels ...
Mutation of protein kinase C phosphorylation site S1076 on α-subunits ...
American Journal of Physiology - Lung Cellular and Molecular Physiology (2009)
Large conductance, calcium- and voltage-activated potassium (BK Ca) channels are important modulators of pulmonary vascular smooth muscle membrane potential, and ...