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Studies of cardiovascular risk factors in polycystic ovary syndrome patients combined with subclinical hypothyroidism
Gynecological Endocrinology
  • Youjuan Pei
  • Aiming Wang
  • Yong Zhao
  • Ling Yan
  • Min Li
  • Richard E. White, Philadelphia College of Osteopathic Medicine
  • Gui Chun Han
Document Type
Article
Publication Date
1-1-2014
Abstract
Objective: To investigate cardiovascular risk factors in women with polycystic ovary syndrome (PCOS) combined with subclinical hypothyroidism (SCH). Patients: A place-controlled study was performed. Group 1: 29 patients with PCOS and SCH; Group II: 35 patients with PCOS and normal thyroid function; and Group III: 34 healthy women with normal thyroid function. Main measure indexes: Total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL) and high-density lipoprotein (HDL), Carotid Arterial Intima-Media Thickness (CIMT), free triiodothyronine 3 (FT3), free triiodothyronine 4 (FT4), thyroid stimulating hormone (TSH), fasting glucose, 1-hour oral glucose tolerance test (OGTT1), 2-hour oral glucose tolerance test (OGTT2), fasting insulin, insulin after 1 hour oral glucose (INS1), insulin after 2 h oral glucose (INS2), HOM-IR ¼ (fasting glucose fasting insulin)/22.5. Results: TG, TC FIN, INS1, and HOM-IR levels were significantly higher, but the mean HDL level was significantly lower in Group I than in Group II (p50.05). LDL cholesterol, FGOGTT1, OGTT2, and insulin after 2 h oral glucose were not significantly higher in Group I than in Group II (p40.05). TG, TC, FIN and INS contents 2 h meal, HOM-IR levels were significantly higher, and the mean HDL cholesterol level was significantly lower in Group I than in Group III (p50.05). Blood glucose levels after 1 and 2 h were not significantly higher in Group I than in the Group III (p40.05). Carotid Arterial Intima-Media Thickness (CIMT) was significantly thicker in Group I than other two groups. Conclusions: The PCOS patients combined with SCH have higher risk of cardiovascular risk factors than in controls or in patients with PCOS.
Comments

This article was published in Gynecological Endocrinology, Volume 30, Issue 8, Pages 553-556.

The published version is available at http://dx.doi.org/10.3109/09513590.2013.829443 .

Copyright © 2014 Informa.

Citation Information
Youjuan Pei, Aiming Wang, Yong Zhao, Ling Yan, et al.. "Studies of cardiovascular risk factors in polycystic ovary syndrome patients combined with subclinical hypothyroidism" Gynecological Endocrinology Vol. 30 Iss. 8 (2014) p. 553 - 556
Available at: http://works.bepress.com/richard_white/7/