Skip to main content
Article
G-protein-coupled estrogen receptor as a new therapeutic target for treating coronary artery disease.
World Journal of Cardiology
  • Guichun Han
  • Richard E. White, Philadelphia College of Osteopathic Medicine
Document Type
Article
Publication Date
6-26-2014
Abstract
Coronary heart disease (CHD) continues to be the greatest mortality risk factor in the developed world. Estrogens are recognized to have great therapeutic potential to treat CHD and other cardiovascular diseases; however, a significant array of potentially debilitating side effects continues to limit their use. Moreover, recent clinical trials have indicated that long-term postmenopausal estrogen therapy may actually be detrimental to cardiovascular health. An exciting new development is the finding that the more recently discovered G-protein-coupled estrogen receptor (GPER) is expressed in coronary arteries-both in coronary endothelium and in smooth muscle within the vascular wall. Accumulating evidence indicates that GPER activation dilates coronary arteries and can also inhibit the proliferation and migration of coronary smooth muscle cells. Thus, selective GPER activation has the potential to increase coronary blood flow and possibly limit the debilitating consequences of coronary atherosclerotic disease. This review will highlight what is currently known regarding the impact of GPER activation on coronary arteries and the potential signaling mechanisms stimulated by GPER agonists in these vessels. A thorough understanding of GPER function in coronary arteries may promote the development of new therapies that would help alleviate CHD, while limiting the potentially dangerous side effects of estrogen therapy.
Comments

This article was published in World Journal Of Cardiology, Volume 6, Issue 6, June 2014.

The published version is available at http://dx.doi.org/ 10.4330/wjc.v6.i6.367

Copyright © 2014 Baishideng.

Citation Information
Guichun Han and Richard E. White. "G-protein-coupled estrogen receptor as a new therapeutic target for treating coronary artery disease." World Journal of Cardiology Vol. 6 Iss. 6 (2014) p. 367 - 375
Available at: http://works.bepress.com/richard_white/25/