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The dual role of TNF in pulmonary edema
Journal of Cardiovascular Disease Research
  • Guang Yang
  • Boris Gorshkov
  • Supriya Sridhar
  • Alexander Verin
  • Rudolf Lucas
  • Jurg Hamacher
  • Richard E. White, Philadelphia College of Osteopathic Medicine
  • Trinad Chakraborty
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Pulmonary edema, a major manifestation of left ventricular heart failure, renal insufficiency, shock, diffuse alveolar damage and lung hypersensitivity states, is a significant medical problem worldwide and can be life-threatening. The proinflammatory cytokine tumor necrosis factor (TNF) has been shown to contribute to the pathogenesis and development of pulmonary edema. However, some recent studies have demonstrated surprisingly that TNF can also promote alveolar fluid reabsorption in vivo and in vitro. This protective effect of the cytokine is mediated by the lectin-like domain of the cytokine, which is spatially distinct from the TNF receptor binding sites. The TIP peptide, a synthetic mimic of the lectinlike domain of TNF, can significantly increase alveolar fluid clearance and improve lung compliance in pulmonary edema models. In this review, we will discuss the dual role of TNF in pulmonary edema. Abbreviations:-tumor necrosis factor (TNF);acute lung injury (ALI);acute respiratory distress syndrome (ARDS);positive end-expiratory pressure (PEEP);epithelial sodium channel (ENaC);neural precursor cell-expressed developmentally downregulated (gene 4) protein (Nedd4-2);serum and glucocorticoid dependent kinase (Sgk-1);insulin-like growth factor 1 (IGF-1);Protein Kinase C (PKC);reactive oxygen species (ROS);myosin light chain (MLC);pneumolysin (PLY);listeriolysin (LLO);interleukin (IL);bronchoalveolar lavage fluids (BALF);Bacillus Calmette-Guerin (BCG);TNF receptor type 1 (TNFR1);TNF receptor type 2 (TNF-R2);.

This article was published in Journal of Cardiovascular Disease Research, Volume 1, Issue 1, Pages 29-36.

The published version is available at .

Copyright © 2010 Elsevier.

Citation Information
Guang Yang, Boris Gorshkov, Supriya Sridhar, Alexander Verin, et al.. "The dual role of TNF in pulmonary edema" Journal of Cardiovascular Disease Research Vol. 1 Iss. 1 (2010) p. 29 - 36
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