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Expression of GPR30, ERα and ERß in endometrium during window of implantation in patients with polycystic ovary syndrome: A pilot study
Gynecological Endocrinology
  • Aiming Wang
  • Lijuan Ji
  • Wei Shang
  • Min Li
  • Lei Chan
  • Richard E. White, Philadelphia College of Osteopathic Medicine
  • Guichun Han
Document Type
Article
Publication Date
1-1-2011
Disciplines
Abstract
Women with polycystic ovary syndrome (PCOS) exhibit a lower pregnancy rate, which may be related to decreased estrogen receptor (ER) expression or endometrial receptivity. We measured expression of ERα, ERß and the novel G protein-coupled ER (GPR30) in endometrium during window of implantation (WOI) in PCOS patients. Fifteen Chinese women with PCOS were compared to 15 normal subjects. Serial trans-vaginal ultrasonic scanner (TVUS) examinations detected follicular development, and endometrial thickness and pattern were assessed via TVUS on the day of ovulation. GPR30 expression was detected in the cytoplasm of endometrial epithelial cells, and was significantly lower in the PCOS group (p0.05), but there was a significant difference in the ultrasonic pattern (p<0.05). Endometrial expression of GPR30, ERα and ERß was decreased during WOI in PCOS patients, and was accompanied by poor endometrial receptivity, low pregnancy rate and higher spontaneous abortions. We propose that restored receptor expression might improve endometrial receptivity and help lower infertility associated with PCOS.
Comments

This article was published in Gynecological Endocrinology, Volume 27, Issue 4, Pages 251-255.

The published version is available at http://dx.doi.org/10.3109/09513590.2010.487584.

Copyright © 2011 Informa.

Citation Information
Aiming Wang, Lijuan Ji, Wei Shang, Min Li, et al.. "Expression of GPR30, ERα and ERß in endometrium during window of implantation in patients with polycystic ovary syndrome: A pilot study" Gynecological Endocrinology Vol. 27 Iss. 4 (2011) p. 251 - 255
Available at: http://works.bepress.com/richard_white/52/