SelectedWorks - Jiang Liu

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Selected Works of Jiang Liu

Associate Professor, Pharmacology, Physiology and Toxicology

Works
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About Jiang Liu

Present	Associate Professor, Pharmacology, Physiology and Toxicology, Marshall University
Institution Organization Position Type Position Title Time Period to Options Current Position Affiliate my profile with this Institution

Medicine and Health Sciences, Endocrine System Diseases, Medical Pharmacology, Medical Physiology, Medical Toxicology, and Endocrinology, Diabetes, and Metabolism

Cardiovascular Disease, Obesity, and Diabetes

Phone: 304-696-7359

Article

The Na/K-ATPase Oxidant Amplification Loop Regulates Aging

Scientific Reports (2018)

Komal Sodhi, Alexandra Nichols, Amrita Mallick, Rebecca L. Klug, et al.

As aging involves oxidant injury, we examined the role of the recently described Na/K-ATPase oxidant amplification loop (NKAL). First, C57Bl6 ...

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Article

Sodium potassium adenosine triphosphatase (Na/K-ATPase) as a therapeutic target ...

Biochemistry and Microbiology (2017)

Xiaofei Wang, Jiang Liu, C. A. Drummond and Joseph I Shapiro

Clinically, patients with significant reductions in renal function present with cardiovascular dysfunction typically termed, uremic cardiomyopathy. It is a progressive ...

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Article

A Student's Guide to giant Viruses Infecting Small Eukaryotes ...

Viruses (2017)

Steven W. Wilhelm, Jordan T. Bird, Kyle S. Bonifer, Benjamin C. Calfee, et al.

The discovery of infectious particles that challenge conventional thoughts concerning “what is a virus” has led to the evolution a ...

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Article

Na/K-ATPase Signaling and Salt Sensitivity: The Role of Oxidative ...

Biochemistry and Microbiology (2017)

Jiang Liu, Yanling Yan and Ying Nie

Other than genetic regulation of salt sensitivity of blood pressure, many factors have been shown to regulate renal sodium handling ...

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Article

Cigarette smoking causes epigenetic changes associated with cardiorenal fibrosis

Biochemistry and Microbiology (2016)

Christopher A. Drummond, Laura E. Crotty Alexander, Steven T. Haller, Xiaoming Fan, et al.

Clinical studies indicate that smoking combustible cigarettes promotes progression of renal and cardiac injury, leading to functional decline in the ...

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Article

Attenuation of Na/K-ATPase Mediated Oxidant Amplification with pNaKtide Ameliorates ...

NYMC Faculty Publications (2016)

Jiang Liu, Jiang Tian, Muhammad Chaudhry, Nader G Abraham, et al.

We have previously reported that the sodium potassium adenosine triphosphatase (Na/K-ATPase) can effect the amplification of reactive oxygen species. In ...

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Article

Attenuation of Na/K-ATPase Mediated Oxidant Amplification with pNaKtide Ameliorates ...

Biochemistry and Microbiology (2016)

Jiang Liu, Jiang Tian, Muhammad Chaudhry, Kyle Maxwell, et al.

We have previously reported that the sodium potassium adenosine triphosphatase (Na/K-ATPase) can effect the amplification of reactive oxygen species. In ...

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Article

Protein Carbonylation of an Amino Acid Residue of the Na ...

Biochemistry and Microbiology (2016)

Yanling Yan, Anna P. Shapiro, Brahma R. Mopidevi, Muhammad Chaudhry, et al.

Background We have demonstrated that cardiotonic steroids, such as ouabain, signaling through the Na/K‐ATPase, regulate sodium reabsorption in the renal ...

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Article

Carbonylation Modification Regulates Na/K-AT PaseSignaling and Salt Sensitivity: A ...

Biochemistry and Microbiology (2016)

Preeya Shah, Rebecca Martin, Yanling Yan, Joseph I Shapiro, et al.

Na/K-ATPase signaling has been implicated in different physiological and pathophysiological conditions. Accumulating evidence indicates that oxidative stress not only regulates ...

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Article

Hiding inside? Intracellular expression of non-glycosylated c-kit protein in cardiac ...

Pharmaceutical Science and Research (2016)

Huilin Shi, Christopher A. Drummond, Xiaoming Fan, Steven T. Haller, et al.

Cardiac progenitor cells including c-kit(+) cells and cardiosphere-derived cells (CDCs) play important roles in cardiac repair and regeneration. CDCs were ...

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Article

Rapamycin Attenuates Cardiac Fibrosis in Experimental Uremic Cardiomyopathy by Reducing ...

Pharmaceutical Science and Research (2016)

Steven T. Haller, Yanling Yan, Christopher A. Drummond, Joe Xie, et al.

Background: Experimental uremic cardiomyopathy causes cardiac fibrosis and is causally related to the increased circulating levels of the cardiotonic steroid, ...

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Article

pNaKtide inhibits Na/K-ATPase reactive oxygen species amplification and attenuates ...

Biochemistry and Microbiology (2015)

Komal Sodhi, Kyle Maxwell, Yanling Yan, Jiang Liu, et al.

Obesity has become a worldwide epidemic and is a major risk factor for metabolic syndrome. Oxidative stress is known to ...

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Article

Reduction of Na/K-ATPase affects cardiac remodeling and increases c-kit ...

Pharmaceutical Science and Research (2014)

Christopher A. Drummond, Moustafa Sayed, Kaleigh L. Evans, Huilin Shi, et al.

The current study examined the role of Na/K-ATPase α1-subunit in animals subjected to 5/6th partial nephrectomy (PNx) using Na/K-ATPase α1-heterozygous ...

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Article

Three-Dimensional Graphene-Polypyrrole Hybrid Electrochemical Actuator

Nanoscale (2012)

Jiang Liu, Z. Wang, Yang Zhao, Huhu Cheng, et al.

The advancement of mechanical actuators benefits from the development of new structural materials with prominent properties. a novel three-dimensional (3D) ...

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Article

Involvement of Reactive Oxygen Species in a Feed-Forward Mechanism of ...

Biochemistry and Microbiology (2013)

Yanling Yan, Anna P. Shapiro, Steven Haller, Vinal Katragadda, et al.

Cardiotonic steroids (such as ouabain) signaling through Na/K-ATPase regulate sodium reabsorption in the renal proximal tubule. We report here that ...

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Article

Passive Immunization Against Marinobufagenin Attenuates Renal Fibrosis and Improves Renal ...

Biochemistry and Microbiology (2013)

Steven T. Haller, Christopher A. Drummond, Yanling Yan, Jiang Liu, et al.

BACKGROUND We have shown that the cardiotonic steroid marinobufagenin (MBG) is elevated in clinical and experimental renal disease, and significantly ...

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Article

CD36 and Na/K-ATPase- α 1 Form a Proinflammatory Signaling ...

Pharmaceutical Science and Research (2013)

David J. Kennedy, Yiliang Chen, Wenxin Huang, Jamie Viterna, et al.

Proatherogenic, hyperlipidemic states demonstrate increases in circulating ligands for scavenger receptor CD36 (eg, oxidized low-density lipoprotein [oxLDL]) and the Na/K-ATPase ...

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Article

Gender differences in the development of uremic cardiomyopathy following partial ...

Biochemistry and Microbiology (2013)

Christopher A. Drummond, George Buddny, Steven T. Haller, Jiang Liu, et al.

Gender difference has been suggested as a risk factor for developing cardiovascular and renal diseases in humans and experimental animals. ...

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Article

Ouabain-Stimulated Trafficking Regulation of the Na/K-ATPase and NHE3 in ...

Pharmaceutical Science and Research (2012)

Yanling Yan, Steven Haller, Anna Shapiro, Nathan Malhotra, et al.

We have demonstrated that ouabain regulates protein trafficking of the Na/K-ATPase a1 subunit and NHE3 (Na/H exchanger, isoform 3) via ...

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Article

Ouabain and Insulin Induce Sodium Pump endocytosis in Renal Epithelium

Pharmaceutical Science and Research (2012)

Shalini Gupta, Yanling Yan, Deepak Malhotra, Jiang Liu, et al.

Cardiotonic steroids signaling through the basolateral sodium pump (Na/K-ATPase) have been shown to alter renal salt handling in intact animals. ...

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Article

Reactive Oxygen Species Modulation of Na/K-ATPase Regulates Fibrosis and ...

Pharmaceutical Science and Research (2011)

Jiang Liu, David J. Kennedy, Yanling Yan and Joseph I. Shapiro

The Na/K-ATPase is the primary force regulating renal sodium handling and plays a key role in both ion homeostasis and ...

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Article

Impairment of Na/K-ATPase Signaling in Renal Proximal Tubule Contributes ...

Pharmaceutical Science and Research (2011)

Jiang Liu, Yanling Yan, Lijun Liu, Zijian Xie, et al.

We have observed that, in renal proximal tubular cells, cardiotonic steroids such as ouabain in vitro signal through Na/K-ATPase, which ...

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Article

The Sodium Pump and Cardiotonic Steroids-induced Signal Transduction Protein Kinases ...

Pharmaceutical Science and Research (2010)

Jiang Liu

The Na/K-ATPase was discovered as an energy transducing ion pump. A major difference between the Na/K-ATPase and other P-type ATPases ...

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Article

Marinobufagenin induces increases in procollagen expression in a process involving ...

Biochemistry and Microbiology (2009)

Jihad Elkareh, Sankaridrug M. Periyasamy, Amjad Shidyak, Sandeep Vetteth, et al.

The cardiotonic steroid marinobufagenin (MBG) has been implicated in the pathogenesis of experimental uremic cardiomyopathy, which is characterized by progressive ...

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Article

Regulation of Apical NHE3 Trafficking by Ouabain-Induced Activation of Basolateral ...

Pharmaceutical Science and Research (2008)

Haiping Cai, Liang Wu, Weikai Qu, Deepak Malhotra, et al.

The long-term effects of ouabain on transepithelial Na+ transport involve transcriptional downregulation of apical Na+/H+ exchanger isoform 3 (NHE3). The ...

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