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Article
Reactive Oxygen Species Modulation of Na/K-ATPase Regulates Fibrosis and Renal Proximal Tubular Sodium Handling
Pharmaceutical Science and Research
  • Jiang Liu, Marshall University
  • David J. Kennedy
  • Yanling Yan, Marshall University
  • Joseph I. Shapiro, MD, Marshall University
Document Type
Article
Publication Date
11-7-2011
Abstract
The Na/K-ATPase is the primary force regulating renal sodium handling and plays a key role in both ion homeostasis and blood pressure regulation. Recently, cardiotonic steroids (CTS)-mediated Na/K-ATPase signaling has been shown to regulate fibrosis, renal proximal tubule (RPT) sodium reabsorption, and experimental Dahl salt-sensitive hypertension in response to a high-salt diet. Reactive oxygen species (ROS) are an important modulator of nephron ion transport. As there is limited knowledge regarding the role of ROS-mediated fibrosis and RPT sodium reabsorption through the Na/K-ATPase, the focus of this review is to examine the possible role of ROS in the regulation of Na/K-ATPase activity, its signaling, fibrosis, and RPT sodium reabsorption.
Comments

The version of record is available from the publisher at http://www.hindawi.com/journals/ijn/2012/381320/. Copyright © 2012 Jiang Liu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. doi:10.1155/2012/381320

Citation Information
Liu J, Kennedy DJ, Yan Y, and Shapiro JI. (2012). “Reactive Oxygen Species Modulation of Na/K-ATPase Regulates Fibrosis and Renal Proximal Tubular Sodium Handling.” International Journal of Nephrology, vol. 2012:381320. 14 pages. PMID: 22518311 (Review)