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About Amy Andreotti

Research in the Andreotti group focuses on a family of intracellular signaling molecules that is exclusively expressed in hematopoeitic cells, in particular the IL-2 inducible tyrosine kinase (Itk) which is expressed in T cells. The Andreotti laboratory makes use of NMR spectroscopy to determine three-dimensional structures of various domains of Itk and related family members. Additionally, NMR and a suite of biochemical techniques are used to examine interactions between domains and to understand the activation and substrate recognition of these enzymes. Elucidating the mechanisms by which T cell signaling pathways are regulated will allow a more complete understanding of how malfunction of the immune response can lead to autoimmune disease states.

Positions

Present Professor, Iowa State University Department of Biochemistry, Biophysics and Molecular Biology
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Education

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19941997 Postdoctoral Fellow, Harvard University
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1994 Ph.D., Princeton University ‐ Chemistry
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1989 A.B., Bowdoin College ‐ Chemistry and Studio Art
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Contact Information

4208 Molecular Biology Building
Dept. of Biochemistry, Biophysics & Molecular Biology
Iowa State University
Ames, IA 50011
515-294-4953

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Peer-Reviewed Articles (17)