Recent Works (27)
DRM02, a novel phosphodiesterase-4 inhibitor with cutaneous anti-inflammatory activity
Tissue Barriers (2020)
Chronic inflammatory skin disorders are frequently associated with impaired skin barrier function. Selective phosphodiesterase-4 (PDE4) inhibition constitutes an effective therapeutic ...
Integrin-linked kinase regulates melanosome trafficking and melanin transfer in melanocytes
Molecular Biology of the Cell (2020)
Melanosomes are melanin-containing organelles that provide pigmentation and protection from solar UV radiation to the skin. In melanocytes, melanosomes mature ...
Integrin-linked kinase and ELMO2 modulate recycling endosomes in keratinocytes
Biochimica et Biophysica Acta - Molecular Cell Research (2016)
The formation of tight cell-cell junctions is essential in the epidermis for its barrier properties. In this tissue, keratinocytes follow ...
Integrin-Linked Kinase Is Indispensable for Keratinocyte Differentiation and Epidermal Barrier ...
Journal of Investigative Dermatology (2016)
A functional permeability barrier is essential to prevent the passage of water and electrolytes, macromolecules, and pathogens through the epidermis. ...
Modulation of type II TGF-β receptor degradation by integrin-linked kinase
Journal of Investigative Dermatology (2015)
Cutaneous responses to injury, infection, and tumor formation involve the activation of resident dermal fibroblasts and subsequent transition to myofibroblasts. ...
ILK modulates epithelial polarity and matrix formation in hair follicles
Molecular Biology of the Cell (2014)
Hair follicle morphogenesis requires coordination of multiple signals and communication between its epithelial and mesenchymal constituents. Cell adhesion protein platforms, ...