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Modulation of type II TGF-β receptor degradation by integrin-linked kinase
Journal of Investigative Dermatology
  • Linda Vi, Western University
  • Stellar Boo, Western University
  • Samar Sayedyahossein, Western University
  • Randeep K. Singh, Western University
  • Sarah Mclean, Western University
  • Gianni M. Di Guglielmo, Western University
  • Lina Dagnino, Western University
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Cutaneous responses to injury, infection, and tumor formation involve the activation of resident dermal fibroblasts and subsequent transition to myofibroblasts. The key for induction of myofibroblast differentiation is the activation of transforming growth factor-β (TGF-β) receptors and stimulation of integrins and their associated proteins, including integrin-linked kinase (ILK). Cross-talk processes between TGF-β and ILK are crucial for myofibroblast formation, as ILK-deficient dermal fibroblasts exhibit impaired responses to TGF-β receptor stimulation. We now show that ILK associates with type II TGF-β receptors (TβRII) in ligand- and receptor kinase activity-independent manners. In cells with targeted Ilk gene inactivation, cellular levels of TβRII are decreased, through mechanisms that involve enhanced ubiquitination and proteasomal degradation. Partitioning of TGF-β receptors into membrane has been linked to proteasome-dependent receptor degradation. We found that interfering with membrane raft formation in ILK-deficient cells restored TβRII levels and signaling. These observations support a model whereby ILK functions in fibroblasts to direct TβRII away from degradative pathways during their differentiation into myofibroblasts.

Citation Information
Linda Vi, Stellar Boo, Samar Sayedyahossein, Randeep K. Singh, et al.. "Modulation of type II TGF-β receptor degradation by integrin-linked kinase" Journal of Investigative Dermatology Vol. 135 Iss. 3 (2015) p. 885 - 894
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