Associate Professor, Anatomy and Cell Biology
Dr. David Hess is a cell biologist researching the use of distinct stem cell subsets for blood cell and blood vessel generation, as well as tissue repair as a possible cell therapy for diseased, damaged, or ischemic tissue.
Children's Health Collaborators: Rodney DeKoter and Peeyush Lala
Dr. Hess's research has grown to include cell transplantation to promote wound healing and blood vessel formation in patients with certain vascular diseases, and to spur regeneration of insulin-producing beta cells in patients with diabetes.
Unique Keywords: Hematopoiesis.
The focus of Dr. Hess’ research is to understand the mechanisms by which distinct stem cell subsets co-ordinate hematopoiesis, angiogenesis, and tissue repair. Ultimately, Dr. Hess is interested in the development of cellular therapies to mediate the repair of diseased, damaged, or ischemic tissues. Specific applications for his work include the use of transplanted human stem cells to promote wound healing and blood vessel formation, and to regenerate insulin-producing beta cells during diabetes.
In an attempt to isolate and study the regenerative functions of human bone marrow-derived stem cells, Dr. Hess' lab has purified multiple (hematopoitic, endothelial, and mesenchymal) stem cell lineages simultaneously using high-speed fluorescence activated cell sorting based on a conserved stem cell function (high aldehyde dehydrogenase activity) and cell surface markers. These progenitor cell lineages can be expanded efficiently in vitroand their regenerative functions are studied by the transplantation in immune deficient mouse models specifically designed to track the contributions of human cells during blood vessel formation during critical limb ischemia, and during the regeneration of islet function in hyperglycemic recipients
Research Focus
- Hematopoietic repopulating function(s) of purified stem cells from various adult sources.
- Transplantation of endothelial progenitor cells to promote angiogenesis in ischemic tissues.
- Transplantation of purified stem cells to regenerate beta-cell function.
- Investigating the mechanisms by which distinct stem cell subsets co-ordinate complex biological processes including hematopoiesis, angiogenesis, and tissue regeneration.
Isolation and transplantation of tumor-initiating stem cells.
MSK Research Areas of Interest
Animal Models, Arthritis, Bioengineering, Biomaterials & Scaffolds, Clinical Outcomes, Drug Delivery, Genetics, Knowledge Translation & Mobilization, Molecular & Cell Biology, Personalized Medicine, Regenerative Medicine, Wound Healing
The focus of Dr. Hess’ research is to understand the mechanisms by which distinct stem cell subsets co-ordinate hematopoiesis, angiogenesis, and tissue repair. Ultimately, Dr. Hess is interested in the development of cellular therapies to mediate the repair of diseased, damaged, or ischemic tissues. Specific applications for his work include the use of transplanted human stem cells to promote wound healing and blood vessel formation in patients with ischemic vascular diseases, and to regenerate insulin-producing beta cells during diabetes.
Research Overview: Mechanisms by which distinct stem cell subsets co-ordinate hematopoiesis, angiogenesis, and tissue repair; Cancer, cardiovascular diseases, diabetes & cellular therapies; Stem cell transplantation
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About David Hess
Dr. David Hess is a cell biologist researching the use of distinct stem cell subsets for blood cell and blood vessel generation, as well as tissue repair as a possible cell therapy for diseased, damaged, or ischemic tissue.
Children's Health Collaborators: Rodney DeKoter and Peeyush Lala
Dr. Hess's research has grown to include cell transplantation to promote wound healing and blood vessel formation in patients with certain vascular diseases, and to spur regeneration of insulin-producing beta cells in patients with diabetes.
Unique Keywords: Hematopoiesis.
The focus of Dr. Hess’ research is to understand the mechanisms by which distinct stem cell subsets co-ordinate hematopoiesis, angiogenesis, and tissue repair. Ultimately, Dr. Hess is interested in the development of cellular therapies to mediate the repair of diseased, damaged, or ischemic tissues. Specific applications for his work include the use of transplanted human stem cells to promote wound healing and blood vessel formation, and to regenerate insulin-producing beta cells during diabetes.
In an attempt to isolate and study the regenerative functions of human bone marrow-derived stem cells, Dr. Hess' lab has purified multiple (hematopoitic, endothelial, and mesenchymal) stem cell lineages simultaneously using high-speed fluorescence activated cell sorting based on a conserved stem cell function (high aldehyde dehydrogenase activity) and cell surface markers. These progenitor cell lineages can be expanded efficiently in vitroand their regenerative functions are studied by the transplantation in immune deficient mouse models specifically designed to track the contributions of human cells during blood vessel formation during critical limb ischemia, and during the regeneration of islet function in hyperglycemic recipients
Research Focus
- Hematopoietic repopulating function(s) of purified stem cells from various adult sources.
- Transplantation of endothelial progenitor cells to promote angiogenesis in ischemic tissues.
- Transplantation of purified stem cells to regenerate beta-cell function.
- Investigating the mechanisms by which distinct stem cell subsets co-ordinate complex biological processes including hematopoiesis, angiogenesis, and tissue regeneration.
Isolation and transplantation of tumor-initiating stem cells.
MSK Research Areas of Interest
Animal Models, Arthritis, Bioengineering, Biomaterials & Scaffolds, Clinical Outcomes, Drug Delivery, Genetics, Knowledge Translation & Mobilization, Molecular & Cell Biology, Personalized Medicine, Regenerative Medicine, Wound Healing
The focus of Dr. Hess’ research is to understand the mechanisms by which distinct stem cell subsets co-ordinate hematopoiesis, angiogenesis, and tissue repair. Ultimately, Dr. Hess is interested in the development of cellular therapies to mediate the repair of diseased, damaged, or ischemic tissues. Specific applications for his work include the use of transplanted human stem cells to promote wound healing and blood vessel formation in patients with ischemic vascular diseases, and to regenerate insulin-producing beta cells during diabetes.
Research Overview: Mechanisms by which distinct stem cell subsets co-ordinate hematopoiesis, angiogenesis, and tissue repair; Cancer, cardiovascular diseases, diabetes & cellular therapies; Stem cell transplantation
| Present | Associate Professor, Western University ‐ Department of Physiology and Pharmacology | |
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| Present | Associate Professor, Western University ‐ Department of Biochemistry | |
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| Present | Associate Professor, Western University ‐ Department of Anatomy and Cell Biology | |
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| Present | Scientist, Lawson Health Research Institute ‐ Children's Health Research Institute (CHRI) | |
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| Present | Scientist, Western University ‐ Robarts Research Institute | |
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