Honors and Awards
- Chin Long Chiang Biostatistics Student of the Year
- Causality in Statistics Education Award
- Gertrude M. Cox Scholarship
- Berkeley Fellow (University of California, Berkeley)
- Director's Award (University of Cambridge, UK)
- Summa Cum Laude (University of Vermont)
- Honors College Scholar (University of Vermont)
- Barry M. Goldwater Scholarship Award
Department of Biostatistics & Epidemiology
School of Public Health & Health Sciences
University of Massachusetts - Amherst
416 Arnold House, 715 North Pleasant St.
Amherst, MA 01003-9304
Association of Implementation of a Universal Testing and Treatment Intervention With HIV Diagnosis, Receipt of Antiretroviral Therapy, and Viral Suppression in East Africa JAMA (2017)
IMPORTANCE Antiretroviral treatment (ART) is now recommended for all HIV-positive persons. UNAIDS has set global targets to diagnose 90% of HIV-positive individuals, treat 90% of diagnosed individuals with ART, and suppress viral replication among 90% ...
Constrained binary classification using ensemble learning: an application to cost-efficient targeted PrEP strategies Statistics in Medicine (2017)
Binary classification problems are ubiquitous in health and social sciences. In many cases, one wishes to balance two competing optimality considerations for a binary classifier. For instance, in resource-limited settings, an human immunodeficiency virus prevention ...
Using a network-based approach and targeted maximum likelihood estimation to evaluate the effect of adding pre-exposure prophylaxis to an ongoing Test-and-Treat trial Clinical Trials (2017)
Background: Several cluster randomized trials are underway to investigate the implementation and effectiveness of a universal test-and-treat strategy on the HIV epidemic in sub-Saharan Africa. We consider nesting studies of pre-exposure prophylaxis (PrEP) within these ...
Adaptive Pre-specification in Randomized Trials With and Without Pair-Matching Statistics in Medicine (2016)
In randomized trials, adjustment for measured covariates during the analysis can reduce variance and increase power. To avoid misleading inference, the analysis plan must be pre-specified. However, it is often unclear a priori which baseline ...
Targeted estimation and inference for the sample average treatment effect in trials with and without pair-matching Statistics in Medicine (2016)
In cluster randomized trials, the study units usually are not a simple random sample from some clearly definedtarget population. Instead, the target population tends to be hypothetical or ill-defined, and the selection of studyunits tends ...
Estimating Effects with Rare Outcomes and High Dimensional Covariates: Knowledge is Power Epidemiologic Methods (2016)
Many of the secondary outcomes in observational studies and randomized trials are rare. Methods for estimating causal effects and associations with rare outcomes, however, are limited, and this represents a missed opportunity for investigation. In ...
Targeted Estimation of Marginal Absolute and Relative Associations in Case-Control Data: An Application in Social Epidemiology Epidemiology (2016)
Background: Case-control studies are useful for rare outcomes, but typical analyses limit investigators to parametric estimation of conditional odds ratios. Several methods exist for obtaining marginal risk differences and risk ratios in a case-control setting, ...
Adaptive pair-matching in randomized trials with unbiased and efficient effect estimation Statistics in Medicine (2015)
In randomized trials, pair-matching is an intuitive design strategy to protect study validity and to potentiallyincrease study power. In a common design, candidate units are identified, and their baseline characteristics usedto create the best n∕2 ...
Adaptive matching in randomized trials and observational studies Journal of Statistical Research (2012)
In many randomized and observational studies the allocation of treatment among a sample of n independent and identically distributed units is a function of the covariates of all sampled units. As a result, the treatment ...
Unpublished Papers (3)
A New Approach to Hierarchical Data Analysis: Targeted Maximum Likelihood Estimation of Cluster-Based Effects Under Interference arXiv (2017)
Estimating the impact of exposures occurring at the cluster-level is of substantial interest. Community randomized trials are often applied to learn about real-world implementation, sustainability, and direct and spill-over effects of interventions with proven individual-level ...
Evaluation of Progress Towards the UNAIDS 90-90-90 HIV Care Cascade: A Description of Statistical Methods Used in an Interim Analysis of the Intervention Communities in the SEARCH Study U.C. Berkeley Division of Biostatistics Working Paper Series (2017)
WHO guidelines call for universal antiretroviral treatment, and UNAIDS has set a global target to virally suppress most HIV-positive individuals. Accurate estimates of population-level coverage at each step of the HIV care cascade (testing, treatment, ...
Why Match in Individually and Cluster Randomized Trials? U.C. Berkeley Division of Biostatistics Working Paper Series (2012)
The decision to match individuals or clusters in randomized trials is motivated by both practical and statistical concerns. Matching protects against chance imbalances in baseline covariate distributions and is thought to improve study credibility. Matching ...
Contributions to Books (1)
R Code for Adaptive Prespecification (2016)
Sample R code and simulations to illustrate estimation and inference for the PATE and SATE with the unadjusted estimator, MLE with a priori-specified adjustment set, TMLE with adaptive pre-specification for initial estimation of outcome regression, and ...
Introduction to Causal Inference (2014)
This course presents a general framework for causal inference. Directed acyclic graphs and non-parametric structural equation models (NPSEM) are used to define the causal model. Target causal parameters are defined using counterfactuals and marginal structural ...
Applications of Targeted Maximum Likelihood Estimation UCSF (2016)
This workshop will introduce participants to a "causal roadmap" approach to Public Health and Medical questions: 1) clear statement of the scientific question, 2) definition of the causal model and parameter of interest, 3) assessment ...
Adaptive Pair-Matching in the SEARCH trial & Estimation of the Intervention Effect Joint Statistical Meetings (JSM) (2014)
In randomized trials, pair-matching is an intuitive design strategy to protect study validity and to potentially increase study power. In a common design, candidate units are identified, and their baseline characteristics used to create the ...