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About Elizabeth Vierling

My research interests are primarily in processes that occur post-transcriptionally and post-translationally to regulate cell function.
A major component of our research program is aimed at understanding the mechanism of action and biological roles of molecular chaperones. Molecular chaperones are a structurally diverse group of highly conserved proteins that share the capacity to bind substrate proteins that are in non-native states. This interaction can facilitate proper protein folding and maturation, protein targeting and dissolution of protein aggregates formed due to stress or disease, giving chaperones a broad impact on normal cell function and stress responses. We have focused on the structure and function of the small heat shock proteins and the HSP100 class of chaperones. In addition, we have an expanding program investigating factors other than chaperones that are essential for organismal stress tolerance, including new work on an enzyme involved in nitric oxide (NO) metabolism, and efforts to understand translational regulation during stress. In striving to address basic biological questions, our research extends from biochemical and protein structural studies to molecular and classical genetic analysis. Our current studies utilize Arabidopsis thaliana and the cyanobacterium Synechocystis sp. PCC6803 as model organisms.


Present Distinguished Professor, Department of Biochemistry and Molecular Biology, University of Massachusetts Amherst

Curriculum Vitae

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Honors and Awards

  • 2013 Distinguished Professors Award
  • 2013 Spotlight Scholar, University of Massachusetts Amherst

Contact Information

Lederle Grad Research Tower 1021J
University of Massachusetts Amherst
Amherst, MA 01003


Anacystis nidulans (1)

cDNA (1)

cDNA clone encoding (1)

chlorophyll/cell (1)

chlorophyll/P700 (1)

chlorplast heat shock protein (3)

eukaryotic superfamily of heat shock proteins (1)

heat shock protein (2)

heat shock protein maize (1)

heat shock proteins (1)

HSP70 homologues in chorloplasts (1)

P700 chlorophyll a-protein (1)

photosystem I (1)

phycobiliproteins/P700 (1)

PSI (1)

PSII (1)

Small HSPs, molecular chaperone activity (7)