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Hussam A. Yacoub, DO, MS

Physician

Disciplines

  • Medicine and Health Sciences
  • Neurology

Research Interests

  • 7/99-8/01 Thesis Research: Laboratory of Molecular Pharmacology, Department of Physiology and Pharmacology, MCP Hahnemann University School of Medicine, Philadelphia PA. • Thesis Objectives: To investigate molecular mechanisms mediating desensitization of the G protein coupled A1-Adenosine receptor in the brain and aged heart, and to determine whether such alterations contribute to tissue vulnerability during ischemic insult.
  • 8/97-6/99 Research Rotations at MCP Hahnemann University School of Medicine, Philadelphia, PA. • Center for Gene Therapy: Investigated the effect of tyrosine hydroxylase transfected primary rat astrocyte cultures on Parkinson’s disease rat models. • Department of Pharmacology & Physiology: Examined the effect of several pharmacological agents norepinephrine release in prepared young and aged rat heart synaptosomes. • Department of Neurobiology/Anatomy: Investigated the involvement of semaphorines in mediating growth of cerebellar neurite explants from the developing mouse brain.
  • Research Assistant at Lehigh University, Bethlehem, PA. •Thesis Objectives: Prepared organic compounds in an organic synthesis laboratory. Overall goal was to isolate an anion transport protein found in proximal convoluted tubule cells of rat kidney nephron.

Discipline

    1. Medicine and Health Sciences 82
    2. Pathology 42
    3. Medical Specialties 25
    4. Surgery 14
    5. Emergency Medicine 10

Research Interest

    1. Cardiology 6
    2. Emergency Medicine 4
    3. Medical Education 3
    4. Surgery 3
    5. Anesthesiology 2
    1. Evidence-Based Medicine 2
    2. Family Medicine 2
    3. Obstetrics and Gynecology 2
    4. Pathology & Laboratory Medicine 2
    5. Pediatrics 2
    6. 1991-1994 1
    7. 1995 Summer Research Fellow-Sonserai Lee, M.S., Knowledge Recovery Foundation. Traveled to various riverside native communities in Peruvian Amazon basin to collect, identify, and discuss local medicinal plants with the indigenous people and the village shaman 1
    8. 5/2000-12/2000 • The Johns Hopkins University, Department of Pathology, Designed and constructed tissue micro-arrays of lung and breast cancers for simultaneous immunohistochemical analysis of multiple tumor samples. 6/2005 •Leiden University, Netherlands, Department of Dermatology, Studied histology and immunohistochemistry of cutaneous lymphomas. 2006 • University of Pittsburgh Division of Molecular Diagnostics, Compared IgH Biomed-2 multiplex PCR assay to in-house PCR assay for detection of immunoglobulin heavy chain gene rearrangement in B-cell lymphoid infiltrates. 2007 •University of Pittsburgh, Division of Molecular Diagnostics, Evaluated three different methods of DNA extraction from formalin-fixed paraffin-embedded skin specimens. 1
    9. 7/99-8/01 Thesis Research: Laboratory of Molecular Pharmacology, Department of Physiology and Pharmacology, MCP Hahnemann University School of Medicine, Philadelphia PA. • Thesis Objectives: To investigate molecular mechanisms mediating desensitization of the G protein coupled A1-Adenosine receptor in the brain and aged heart, and to determine whether such alterations contribute to tissue vulnerability during ischemic insult. 1
    10. 8/97-6/99 Research Rotations at MCP Hahnemann University School of Medicine, Philadelphia, PA. • Center for Gene Therapy: Investigated the effect of tyrosine hydroxylase transfected primary rat astrocyte cultures on Parkinson’s disease rat models. • Department of Pharmacology & Physiology: Examined the effect of several pharmacological agents norepinephrine release in prepared young and aged rat heart synaptosomes. • Department of Neurobiology/Anatomy: Investigated the involvement of semaphorines in mediating growth of cerebellar neurite explants from the developing mouse brain. 1
    11. Acute Myelogenous Leukemia 1
    12. Anatomic Pathology 1
    13. Autism 1
    14. Bone marrow and stem cell transplantation 1
    15. Burn/Trauma- Surgical Critical Care 1
    16. Cardiac Surgery 1
    17. Cardiothoracic Surgery 1
    18. Cardiovascular Anesthesia 1
    19. Cardiovascular Disease 1
    20. Chiari Malformation 1
    21. Content Management 1
    22. Creating a digital study set of gastrointestinal pathology to be used for education for medical students( USF and others) rotating through our department. 1
    23. Dana Scholar Research Project (MC) Irvin Schmoyer, Ph.D., Biology Dept., Muhlenberg College. Developed a picture library of structural aspects of normal cells using fluorescent microscopy 1
    24. Detecting Isolated Tumor Cells in Body Effusion Cytology Specimens. 1
    25. Education 1
    26. Gender Medicine 1
    27. Graft-versus-host disease 1
    28. Gynecologic Oncology 1
    29. Gynecologic oncology group clinical trials 1
    30. Hand Surgery 1
    31. Hand surgery 1
    32. Health Care Informatics 1
    33. Hematology-Medical Oncology 1
    34. Immunobiology of transplantation 1
    35. Improving surgical outcomes through crowdsourcing (CSATS) 1
    36. Infectious Disease 1
    37. July 2016 to current, Key Opinion Leader, for Study 364 for Long-term, open-label, Phase III trial of ESL (eslicarbazepine acetate) _Aptiom in children and adolescents (4–17 years) with Partial Onset Seizures. Ltd.Sunovion Pharmaceuticals Inc. Contact person: Romy Nocera PhD Director, Medical Science Liaison Sunovion Pharmaceuticals 1
    38. Library Science 1
    39. Library Services 1
    40. Lung Tissue Research Consortium (LTRC), July 2010 – November 2014 1
    41. Lung Tissue Research Consortium (LTRC), July 2010 – November 2014, National Institute of Health (NIH). Co-investigator 5%. 1
    42. Lymphoproliferative disorders 1
    43. Master’s Thesis, 1992, University College Dublin, Ireland – The Spectrum of Immunodeficiency Related Lymphoproliferative Disease: A Histopathological and In-situ Hybridization Study. 1
    44. Maternal Fetal Medicine 1
    45. Mathematical modeling of immune reconstitution 1

Organization

    1. Department of Pathology 17
    2. Health Network Laboratories 13
    3. Department of Surgery 12
    4. Department of Emergency Medicine 10
    5. Department of Medicine 9

Position

    1. Physician 105
    2. Faculty Member 3
    3. Healthcare Administrator 3
    4. Fellow 2
    5. Librarian 2