|Present||Professor of Biochemistry and Molecular Biology, Dept. of Bio-Medical Sciences, Philadelphia College of Osteopathic Medicine ‐ Department of Bio-Medical Sciences|
|2015 - Present||Regulation of DNA methylation and demethylation by inflammatory cytokines|
|2010 - 2011||Effects of nicotine and glucose on production of inflammatory mediators in response to IL-1 and LPS in human gingival fibroblasts and CAL27 oral cancer cells|
|2004 - 2010||Transcriptional regulation of matrix metalloproteinase 3|
|NIH - R15 DE16277|
|Research Supplement to Promote Diversity in Health-related Research|
|1997 - 2003||IL-1 Regulation of MMP Genes in Human Gingival Fibroblasts|
|NIH - R29 DE12096-01|
|Supplement for Underrepresented Minorities|
|1995 - 1997||IL-1 Regulation of MMP Genes in Human Gingival Fibroblasts|
|NIH - RO3 DE11577-01|
Professional Service and Affiliations
|Present||Member, American Society for Biochemistry and Molecular Biology||Present||Member, American Society of Genetics||Present||Member, Sigma Xi - PCOM Chapter|
- Molecular Biology
- Molecular Basis of Medicine
|1992||PhD, Temple University School of Medicine ‐ Microbiology and Immunology|
|1987||BS, University of Maine ‐ Microbiology|
Scholarly Articles (21)
Zinc-Binding Protein-89 (ZBP-89) Cooperates with NF-kB to Regulate Expression of ...
Biochemical and biophysical research communications (2016)
Matrix metalloproteinases (MMPs) have both protective and pathological roles in inflammation, and transcriptional mechanisms are important in regulating physiological levels ...
Expression of transcription factor zinc-binding protein-89 (ZBP-89) is inhibited by ...
Pathology and Laboratory Medicine International (2009)
Zinc-binding protein-89 (ZBP-89; ZNF148, BERF-1, BFCOL-1) is a zinc-finger transcription factor of the Kruppel family. It has been shown to ...
Interleukin-4 Inhibition of Interleukin-1-Induced Expression of Matrix Metalloproteinase-3 (MMP-3) is ...
BMC Molecular Biology (2007)
BACKGROUND: Interleukin 4 (IL-4) has been shown to suppress interleukin-1 (IL-1) induced expression of matrix metalloproteinase-3 (MMP-3) in human synovial ...
Induction of bone morphogenetic protein-2 by interleukin-1 in human fibroblasts
Biochemical and biophysical research communications (1998)
Rheumatoid arthritis and periodontitis are chronic inflammatory diseases associated with tissue destruction that is mediated in part by elevated levels ...