SelectedWorks - Roland A. Cooper

Contact

Selected Works of Roland A. Cooper

Professor

Dr. Cooper joined the department in 2011. His NIH-funded research is focused on the molecular mechanism of drug action and resistance in the human malaria parasite, Plasmodium falciparum. His projects are based both in the laboratory and Uganda. Dr. Cooper teaches Advanced Genetics, Medical Parasitology and Research Methodology.

Media Contact

Works
About

×

About Roland A. Cooper

Dr. Cooper joined the department in 2011. His NIH-funded research is focused on the molecular mechanism of drug action and resistance in the human malaria parasite, Plasmodium falciparum. His projects are based both in the laboratory and Uganda. Dr. Cooper teaches Advanced Genetics, Medical Parasitology and Research Methodology.

2011 - Present	Professor, Dominican University of California ‐ Department of Natural Sciences and Mathematics
Institution Organization Position Type Position Title Time Period to Options Current Position Affiliate my profile with this Institution

Genetics and Parasitology

Malaria, Antimaliarial drugs, Parasitology, Genetics, Public Health, and Pharmacology

Biological Sciences at Dominican University of California

Dominican University of California

50 Acacia Ave.

San Rafael, CA 94901

415.482.1887

Email:

Articles (56)

Preclinical characterization and target validation of the antimalarial pantothenamide MMV693183.

Natural Sciences and Mathematics | Faculty Scholarship (2022)

Laura E. de Vries, Patrick A. M. Jansen, Catalina Barcelo, Justin Munro, et al.

Drug resistance and a dire lack of transmission-blocking antimalarials hamper malaria elimination. Here, we present the pantothenamide MMV693183 as a ...

Discovery and Preclinical Pharmacology of INE963, a Potent and Fast-Acting ...

Natural Sciences and Mathematics | Faculty Scholarship (2022)

Benjamin R. Taft, Fumiaki Yokokawa, Tom Kirrane, Anne-Catherine Mata, et al.

A series of 5-aryl-2-amino-imidazothiadiazole (ITD) derivatives were identified by a phenotype-based high-throughput screening using a blood stage Plasmodium falciparum (Pf) ...

Can repurposing drugs play a role in malaria control?

Natural Sciences and Mathematics | Faculty Scholarship (2021)

Roland A. Cooper and Laura Kirkman

Innovative drug treatments for malaria, optimally with novel targets, are needed to combat the threat of parasite drug resistance. As ...

Associations between Varied Susceptibilities to PfATP4 Inhibitors and Genotypes in ...

Natural Sciences and Mathematics | Faculty Scholarship (2021)

Oriana Kreutzfeld, Stephanie A. Rasmussen, Aarti A. Ramanathan, Patrick K. Tumwebaze, et al.

Among novel compounds under recent investigation as potential new antimalarial drugs are three independently developed inhibitors of the Plasmodium falciparum ...

Drug susceptibility of Plasmodium falciparum in eastern Uganda: a longitudinal ...

Natural Sciences and Mathematics | Faculty Scholarship (2021)

Patrick K. Tumwebaze, Thomas Katairo, Martin Okitwi, Oswald Byaruhanga, et al.

Background: Treatment and control of malaria depends on artemisinin-based combination therapies (ACTs) and is challenged by drug resistance, but thus ...

The antimalarial MMV688533 provides potential for single-dose cures with a ...

Natural Sciences and Mathematics | Faculty Scholarship (2021)

James M. Murithi, Cécile Pascal, Jade Bath, Xavier Boulenc, et al.

The emergence and spread of Plasmodium falciparum resistance to first-line antimalarials creates an imperative to identify and develop potent preclinical ...

The antimalarial MMV688533 provides potential for single-dose cures with a ...

Natural Sciences and Mathematics | Faculty Scholarship (2021)

James M Murithi, Cécile Pascal, Jade Bath, Xavier Boulenc, et al.

The emergence and spread of Plasmodium falciparum resistance to first-line antimalarials creates an imperative to identify and develop potent preclinical ...

Balanced impacts of fitness and drug pressure on the evolution ...

Natural Sciences and Mathematics | Faculty Scholarship (2021)

Marvin Duvalsaint, Melissa D. Conrad, Stephen Tukwasibwe, Patrick K. Tumwebaze, et al.

BACKGROUND: Anti-malarial drug resistance may be limited by decreased fitness in resistant parasites. Important contributors to resistance are mutations in ...

Potent Antimalarials with Development Potential Identified by Structure-Guided Computational Optimization ...

Natural Sciences and Mathematics | Faculty Scholarship (2021)

Michael J Palmer, Xiaoyi Deng, Shawn Watts, Goran Krilov, et al.

Dihydroorotate dehydrogenase (DHODH) has been clinically validated as a target for the development of new antimalarials. Experience with clinical candidate ...

Development of a Highly Selective Plasmodium falciparum Proteasome Inhibitor with ...

Natural Sciences and Mathematics | Faculty Scholarship (2021)

Wenhu Zhan, Hao Zhang, John Ginn, Annie Leung, et al.

Plasmodium falciparum proteasome (Pf20S) inhibitors are active against Plasmodium at multiple stages-erythrocytic, gametocyte, liver, and gamete activation stages-indicating that selective ...

Changing Prevalence of Potential Mediators of Aminoquinoline, Antifolate, and Artemisinin ...

Natural Sciences and Mathematics | Faculty Scholarship (2021)

Victor Asua, Melissa D. Conrad, Ozkan Aydemir, Marvin Duvalsaint, et al.

BACKGROUND: In Uganda, artemether-lumefantrine is recommended for malaria treatment and sulfadoxine-pyrimethamine for chemoprevention during pregnancy, but drug resistance may limit ...

Lead Optimization of Second-Generation Acridones as Broad-Spectrum Antimalarials.

Natural Sciences and Mathematics | Faculty Scholarship (2020)

Papireddy Kancharla, Rozalia A. Dodean, Yuexin Li, Sovitj Pou, et al.

The global impact of malaria remains staggering despite extensive efforts to eradicate the disease. With increasing drug resistance and the ...

Plasmodium falciparum Resistance to a Lead Benzoxaborole Due to Blocked ...

Natural Sciences and Mathematics | Faculty Scholarship (2020)

Kirthana M. V. Sindhe, Wesley Wu, Jenny Legac, Yong-Kang Zhang, et al.

New antimalarial drugs are needed. The benzoxaborole AN13762 showed excellent activity against cultured Plasmodium falciparum, against fresh Ugandan P. falciparum ...

Improvement of Asparagine Ethylenediamines as Anti-malarial

Natural Sciences and Mathematics | Faculty Scholarship (2019)

Wenhu Zhan, Joseph Visone, Tierra Ouellette, Jacob C. Harris, et al.

The Plasmodium proteasome (Pf20S) emerged as a target for antimalarials. Pf20S inhibitors are active at multiple stages of the parasite ...

Discovery and Structural Optimization of Acridones as Broad-Spectrum Antimalarials.

Natural Sciences and Mathematics | Faculty Scholarship (2019)

Rozalia A. Dodean, Papireddy Kancharla, Yuexin Li, Victor Melendez, et al.

Malaria remains one of the deadliest diseases in the world today. Novel chemoprophylactic and chemotherapeutic antimalarials are needed to support ...

Antimalarial proteasome inhibitor reveals collateral sensitivity from intersubunit interactions and ...

Natural Sciences and Mathematics | Faculty Scholarship (2018)

Laura A. Kirkman, Wenhu Zhan, Joseph Visone, Alexis Dziedziech, et al.

We describe noncovalent, reversible asparagine ethylenediamine (AsnEDA) inhibitors of the Plasmodium falciparum proteasome (Pf20S) β5 subunit that spare all active ...

Changing Antimalarial Drug Sensitivities in Uganda.

Natural Sciences and Mathematics | Faculty Scholarship (2017)

Stephanie A. Rasmussen, Frida G. Ceja, Melissa D. Conrad, Patrick K. Tumwebaze, et al.

Dihydroartemisinin-piperaquine (DP) has demonstrated excellent efficacy for the treatment and prevention of malaria in Uganda. However, resistance to both components ...

A Variant PfCRT Isoform Can Contribute to Plasmodium Falciparum Resistance ...

Satish K. Dhingra, Devasha Redhi, Jill M. Combrinck, Tomas Yeo, et al.

Current efforts to reduce the global burden of malaria are threatened by the rapid spread throughout Asia of Plasmodium falciparum ...

A potent antimalarial benzoxaborole targets a Plasmodium falciparum cleavage and ...

Natural Sciences and Mathematics | Faculty Scholarship (2017)

Ebere Sonoiki, Caroline L. Ng, Marcus C. S. Lee, Denghui Guo, et al.

Benzoxaboroles are effective against bacterial, fungal and protozoan pathogens. We report potent activity of the benzoxaborole AN3661 against Plasmodium falciparum ...

Antimalarial Benzoxaboroles Target Plasmodium falciparum Leucyl-tRNA Synthetase.

Natural Sciences and Mathematics | Faculty Scholarship (2016)

Ebere Sonoiki, Andres Palencia, Denghui Guo, Vida Ahyong, et al.

There is a need for new antimalarials, ideally with novel mechanisms of action. Benzoxaboroles have been shown to be active ...

Mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, enlarge ...

Scientific Reports (2015)

Serena Pulcini, Henry M. Staines, Andrew H. Lee, Sarah H. Shafik, et al.

Mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, are the major determinant of chloroquine resistance in this lethal human ...

Lack of Artemisinin Resistance in Plasmodium falciparum in Uganda Based ...

Antimicrobial Agents and Chemotherapy (2015)

Roland A. Cooper, Melissa D. Conrad, Quentin D. Watson, Stephanie J. Huezo, et al.

We evaluated markers of artemisinin resistance in Plasmodium falciparum isolated in Kampala in 2014. By standard in vitro assays, all ...

Impact of Antimalarial Treatment and Chemoprevention on the Drug Sensitivity ...

Antimicrobial Agents and Chemotherapy (2015)

Patrick Tumwebaze, Melissa D. Conrad, Andrew Walakira, Norbert LeClair, et al.

Changing treatment practices may be selecting for changes in the drug sensitivity of malaria parasites. We characterized ex vivo drug ...

Mutations in the Plasmodium falciparum Chloroquine Resistance Transporter, PfCRT, Enlarge ...

Scientific Reports (2015)

Serena Pulcini, Henry M. Staines, Andrew H. Lee, Sarah H. Shafik, et al.

Mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, are the major determinant of chloroquine resistance in this lethal human ...

Investigating the Antimalarial Action of 1,2,4-Trioxolanes with Fluorescent ...

Journal of Medicinal Chemistry (2012)

Carmony L. Hartwig, Erica M. W. Lauterwasser, Sumit S. Mahajan, Jonathan M. Hoke, et al.

The 1,2,4-trioxolanes are a new class of synthetic peroxidic antimalarials currently in human clinical trials. The well known reactivity of ...