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About Melvyn D. Goldfinger

Research Interests:
CNS and PNS Processing of Digital and Analog Information
Research in this area addresses two basic mechanisms of electrical information processing in the nervous system. In each case, both experimental and theoretical approaches are used. First, the ability of neuronal circuits to process wide-band random information is studied in peripheral axons and in the CNS Cuneate Nucleus. Random-stimulus probes elicit impulse or population responses, which are analyzed with various stochastic (e.g., interval distributions; autocorrelation functions) and frequency-domain (FFT-based) estimators. To date, this research has found that neuronal elements can efficiently carry wide-band information despite some frequency-limiting components (e.g., chemical synapses; channel inactivation). Second, the ability of branched axons to efficiently spread information is studied with mathematical models (NSF-supported project). To date, this research has found that branched axons have a remarkably high intrinsic ability to propagate impulses within their arborization. This capability is very sensitive to the mathematical methods and physical assumptions used in the simulations. A third research area addresses the role of extracellular neurochemicals in information processing by the Cuneate Nucleus. To date, this work has developed precise measurement of putative amino acid neurotransmitters in CSF, identified amino acids released during synaptic transmission in the cuneate nucleus, and demonstrated amino acid gradients between CSF and extracellular fluid.


Present Associate Professor, Wright State University Neuroscience, Cell Biology & Physiology

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Contact Information

Medical Sciences Building 065
(937) 775-4180


Articles (22)

Contributions to Books (1)