|March 2011 - Present||Co-Founder and Chief Science Officer, ProteaPex Therapeutics, Inc|
|Present||Professor, Dept. of Anatomy, Philadelphia College of Osteopathic Medicine ‐ Department of Bio-Medical Sciences|
|2013 - 2015||Inactivation of Matrix Metalloproteinase-8 by Extracellular Matrix Protection Factor -2 in Dentin Cavity Walls|
|Schoenleber Pilot Grant|
|2013 - 2014||Development of an in vitro, whole tooth model to study effects of endogenous matrix metalloprotease activity on resin restorations|
|2011 - 2014||Effect of Liposuction Technique on the Viability and Differentiation of Adipose Derived Stem Cells|
|Commonwealth Universal Research Enhancement (CURE) Program|
|2005 - 2009||MPS VI and I feline model|
|2005 - 2007||Biomarkers and treatments for joint pathology in MPS VI|
|National MPS Society|
|2002 - 2007||MPS VII canine model|
|2003 - 2005||Joint pathology in MPS VI|
|National MPS Society|
Professional Service and Affiliations
|2010 - Present||Reviewer, Cell Transplantation||2010 - Present||Anatomy Program Organizer, PCOM Take Your Daughters and Sons to Work Day||2009 - Present||Reviewer, Cytokines||2008 - Present||President, PCOM Chapter, Sigma Xi Research Society||2008 - Present||Reviewer, The Open Endocrinology Journal||2007 - Present||Reviewer, Journal of Biological Chemistry||2007 - Present||Reviewer, Journal of Cellular Physiology||2007 - Present||Anatomy Program Organizer, PCOM National Youth Leadership Forum||2003 - Present||Organizer, PCOM Sigma Xi Annual Research Forum||2013||Co-Chair, PCOM Faculty Forum||2011 - 2013||Organizer, PCOM Annual Research Day||2008 - 2013||Chair, PCOM Research Committee||2007 - 2010||Chair, PCOM Anatomy Department Faculty Search Committee||2009||Moderator, Small Group PCOM Research Retreat||2008 - 2009||Chair, PCOM Anatomy Department Technician Search Committee||2006 - 2007||Faculty-at-large Representative to Executive Faculty, PCOM||2005 - 2006||Chair, PCOM Adhoc Committee on Research Personnel||2003 - 2005||Vice President, PCOM Chapter, Sigma Xi Research Society|
Honors and Awards
- National Catholic Education Association Distinguished Graduate Award 2014
- People’s Choice Award 2012, Wharton Business Plan Competition
- University City Science Center QED Proof-of-Concept Program Top Ten Finalist 2010: “Metalloprotease peptide derivative therapeutics for osteoarthritis.”
- East Coast Connective Tissue Society Young Investigator Award 1999: “MMP-13 expression during chondrocyte maturation.”
- Orthopaedic Research Society New Investigator Recognition Award 1997: “Changes in TGFß activation and isoform profiles accompany endochondral ossification.”
- Orthopaedic Research Society New Investigator Recognition Award Semi-Finalist 1996: “Endogenously produced articular chondrocyte factors inhibit growth plate chondrocyte maturation.”
|1992||PhD, Thomas Jefferson School of Law ‐ Developmental Biology/Teratology|
|1986||BS, Drexel University ‐ Biology|
Scholarly Articles (24)
Assaying Endogenous Matrix Metalloproteinases (MMPs) in Acid-etched Dentinal Cavity Walls
Dental Materials Journal (2019)
Endogenous dentinal matrix metalloproteinases (MMPs) have been implicated in the auto-degradation of collagen fibrils within resin infiltrated layers of dentinal ...
Radiographic Evaluation of Bones and Joints in Mucopolysaccharidosis I and ...
Molecular Genetics & Metabolism (2008)
Mucopolysaccharidosis I (MPS I) and MPS VII are due to deficient activity of the glycosaminoglycan-degrading lysosomal enzymes alpha-L-iduronidase and beta-glucuronidase, ...
The osteopetrotic mutation toothless (tl) is a loss-of-function frameshift mutation ...
Proceedings of the National Academy of Sciences of the United States of America (2002)
The toothless (tl) mutation in the rat is a naturally occurring, autosomal recessive mutation resulting in a profound deficiency of ...
Activation of transforming growth factor ß in chondrocytes undergoing endochondral ...
Journal of Bone and Mineral Research (2001)
Transforming growth factor ß (TGF-ß) has well-documented roles in chondrocyte maturation and endochondral ossification, but the mechanisms of TGF-ß activation ...
Utilization of Bone Morphogenetic Protein Receptors during Chondrocyte Maturation.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research (2000)
Cartilage from the upper, cephalic portion of embryonic chick sternums undergoes hypertrophy, while the lower, caudal portion of the sternum ...
Articular chondrocytes produce factors that inhibit maturation of sternal chondrocytes ...
Journal of Bone and Mineral Research (1997)
Under normal conditions, articular chondrocytes persist throughout postnatal life, whereas 'transient' chondrocytes, which constitute the bulk of prenatal and early ...
Transforming growth factor-ß modulation of glycosaminoglycan production by mesenchymal cells ...
Developmental biology (1991)
Development of the mammalian secondary palate requires proper production of the extracellular matrix, particularly glycosaminoglycans (GAGs) and collagen. Endogenous factors ...