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About Marina D'Angelo

Dr. D’Angelo has served as Course Director for the Cellular Anatomy portion of SPOM in the DO curriculum since 2005 and participant in the Histology course for the M.S. in Biomedical sciences since 2001. In addition, Dr. D’Angelo participates in the Gross Anatomy courses for the MS in Biomedical Sciences, the Physician Assistants program and the PhD in Physical Therapy program from Widener University. Her responsibilities include organization and presentation of lectures in a team-taught program and assistance of the students in the laboratory portion of the courses.

Co-Founder and Chief Science Officer, ProteaPex Therapeutics, LLC

ProteaPex Therapeutics, LLC has developed an innovative disease modifying therapeutic technology to treat post-traumatic osteoarthritis (PTOA). This new class of therapeutic, Extracellular Matrix Protection Factor™ (ECPF) is a novel, safe and effective intra-joint injection that reduces the pain and damage caused by PTOA. According to the World Health Organization, over 10% of the world’s population aged 60 or older has been diagnosed with osteoarthritis (OA), with 80% of the population aged 65 and older exhibiting radiographic evidence of OA. Unfortunately, the current standard of care is directed at later stages of the disease with the only attainable goal being relief from pain and improvement of joint function. A critical research goal for our group is the development of disease modifying OA drugs (DMOADs) that would target the early stages of OA. The company is currently focused on developing therapeutics for the veterinary market and has a broad base of products for treatment of orthopedic, dental and wound healing in both the veterinary and human markets. The co-founders of ProteaPex Therapeutics have over 30 years combined experience in the fields of skeletal biology, osteoarthritis and peptide design. In April 2014, ProteaPex Therapeutics was issued a patent on the "Compositions and Methods for Inhibition of MMP13:MMP-Substrate Interactions” by the US Patent Office.

Matrix Metalloprotease Production in the Dentin/Resin Hybrid Layer:
Bacterial and enzymatic degradation of adhesive bonding agents at adhesive/tooth interfaces compromises the long-term inhibition of bacterial leakage and prevention of secondary caries around composite resin restorations. It can be expected that blocking enzymatic degradation at the interface coupled with the elimination of invading bacteria will prolong the life expectancy of resin restorations. However, conclusive clinical evidence for a relationship between gap formation following enzymatic degradation and bacterial involvement at resin/tooth interfaces does not exist. The overarching hypothesis of the project is that endogenous MMPs, released and activated by adhesive procedures, hydrolyse collagen fibrils at resin/dentin interfaces compromising bond durability. In order to test this hypothesis, we must first demonstrate that endogenous MMPs can be measured in the dentin from the cavity wall of a single tooth, and which MMPs are the major players to be inhibited clinically.

Positions

March 2011 - Present Co-Founder and Chief Science Officer, ProteaPex Therapeutics, Inc
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Present Professor, Dept. of Anatomy, Philadelphia College of Osteopathic Medicine Department of Bio-Medical Sciences
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Grants

2013 - 2015 Inactivation of Matrix Metalloproteinase-8 by Extracellular Matrix Protection Factor -2 in Dentin Cavity Walls
Schoenleber Pilot Grant
2013 - 2014 Development of an in vitro, whole tooth model to study effects of endogenous matrix metalloprotease activity on resin restorations
CCDA
2011 - 2014 Effect of Liposuction Technique on the Viability and Differentiation of Adipose Derived Stem Cells
Commonwealth Universal Research Enhancement (CURE) Program
2005 - 2009 MPS VI and I feline model
NIDDK
Role: Collaborator
2005 - 2007 Biomarkers and treatments for joint pathology in MPS VI
National MPS Society
Role: Collaborator
2002 - 2007 MPS VII canine model
NIDDK
Role: Collaborator
2003 - 2005 Joint pathology in MPS VI
National MPS Society
Role: Collaborator
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Professional Service and Affiliations

2010 - Present Reviewer, Cell Transplantation
2010 - Present Anatomy Program Organizer, PCOM Take Your Daughters and Sons to Work Day
2009 - Present Reviewer, Cytokines
2008 - Present President, PCOM Chapter, Sigma Xi Research Society
2008 - Present Reviewer, The Open Endocrinology Journal
2007 - Present Reviewer, Journal of Biological Chemistry
2007 - Present Reviewer, Journal of Cellular Physiology
2007 - Present Anatomy Program Organizer, PCOM National Youth Leadership Forum
2003 - Present Organizer, PCOM Sigma Xi Annual Research Forum
2013 Co-Chair, PCOM Faculty Forum
2011 - 2013 Organizer, PCOM Annual Research Day
2008 - 2013 Chair, PCOM Research Committee
2007 - 2010 Chair, PCOM Anatomy Department Faculty Search Committee
2009 Moderator, Small Group PCOM Research Retreat
2008 - 2009 Chair, PCOM Anatomy Department Technician Search Committee
2006 - 2007 Faculty-at-large Representative to Executive Faculty, PCOM
2005 - 2006 Chair, PCOM Adhoc Committee on Research Personnel
2003 - 2005 Vice President, PCOM Chapter, Sigma Xi Research Society
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Honors and Awards

  • National Catholic Education Association Distinguished Graduate Award 2014
  • People’s Choice Award 2012, Wharton Business Plan Competition
  • University City Science Center QED Proof-of-Concept Program Top Ten Finalist 2010: “Metalloprotease peptide derivative therapeutics for osteoarthritis.”
  • East Coast Connective Tissue Society Young Investigator Award 1999: “MMP-13 expression during chondrocyte maturation.”
  • Orthopaedic Research Society New Investigator Recognition Award 1997: “Changes in TGFß activation and isoform profiles accompany endochondral ossification.”
  • Orthopaedic Research Society New Investigator Recognition Award Semi-Finalist 1996: “Endogenously produced articular chondrocyte factors inhibit growth plate chondrocyte maturation.”

Education

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1992 PhD, Thomas Jefferson School of Law ‐ Developmental Biology/Teratology
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1986 BS, Drexel University ‐ Biology
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Contact Information

P: 215-871-6525

Email:


Scholarly Articles (23)

Contributions to Books (1)

Patents (1)