|Present||Professor of Microbiology and Immunology, Philadelphia College of Osteopathic Medicine ‐ Department of Bio-Medical Sciences|
|2012 - 2015||Evaluation of tetrahydrobiopterin/dihydrobiopterin ratio in vascular injury tissues|
|Pennsylvania State Tobacco Grant|
|2008 - 2011||In vivo and ex vivo mechanisms related to eNOS uncoupling during Reperfusion|
|National, Heart, Lung and Blood Institute of the NIH - 2 R15 HL076235-02|
|2009 - 2010||Tetrahydrobiopterin (BH4) and dihydrobiopterin (BH2) in leukocyte-endothelium interactions by using intravital microscopy|
|Center for Chronic Disorders of Aging (CCDA) at PCOM|
|2008||Administration of Protein Kinase C Beta II Inhibitor During Extracorporeal Shock Wave Lithotripsy Reduces Free Radical Production|
|Center for Chronic Disorders of Aging at PCOM|
|2004 - 2007||Protein Kinase C isoform inhibition in cardiac ischemia/reperfusion|
|National, Heart, Lung and Blood Institute of the NIH - R15 HL076235|
|Role: PI at PCOM|
|2003 - 2006||Proposed role of endothelial long chain fatty acyl CoA synthetase in the development of post-menopausal hypertension|
|Women’s Health Research Institute, Texas Tech University Health Sciences Center (TTUHSC) at Amarillo|
|Colleague(s): Margaret T. Weis (Co-PI)|
Professional Service and Affiliations
|2012 - Present||Reviewer, Journal of Renin-Angiotensin-Aldosterone-System||2007 - Present||Reviewer, Journal of Cellular Physiology||2005 - Present||Reviewer, Journal of Pharmacology and Experimental Therapeutics||2004 - Present||Reviewer, Biochemica et Biophysica Acta-Proteins and Proteomics||2004 - Present||Reviewer, British Journal of Pharmacology|
Honors and Awards
- 2013-2014 Professor of the Year Award presented by the PCOM DO Class of 2017
- 1999-2001 National Heart, Lung & Blood Institute Training Grant HL-07599NHH, National Service Research Award
|1998||PhD, Philadelphia College of Pharmacy and Science ‐ Pharmacology|
|1986||BA, Immaculata College ‐ Biology/Psychology|
|1980||AS, Pennsylvania State University ‐ Hotel/Food Service Management|
Scholarly Articles (35)
Mitochondrial targeted antioxidants, mitoquinone and SKQ1, not vitamin C, mitigate ...
BMC Pharmacology & Toxicology (2021)
BACKGROUND: Preconditioning of the heart ameliorates doxorubicin (Dox)-induced cardiotoxicity. We tested whether pretreating cardiomyocytes by mitochondrial-targeted antioxidants, mitoquinone (MitoQ) or ...
Inhibition of Long Chain Fatty Ccyl-CoA Synthetase (ACSL) and Ischemia ...
Bioorganic & Medicinal Chemistry Letters (2014)
Various triacsin C analogs, containing different alkenyl chains and carboxylic acid bioisoteres including 4-aminobenzoic acid, isothiazolidine dioxide, hydroxylamine, hydroxytriazene, and ...
The Role of Tetrahydrobiopterin and Dihydrobiopterin in Ischemia/Reperfusion Injury ...
Advances in Pharmacological Sciences (2010)
Reduced nitric oxide (NO) bioavailability and increased oxidative stress are major factors mediating ischemia/reperfusion (I/R) injury. Tetrahydrobiopterin (BH(4)) is an ...
Calcium-Activated Chloride Current Contributes to Action Potential Alternations in Left ...
American Journal of Physiology-Heart and Circulatory Physiology (2008)
T-wave alternans, characterized by a beat-to-beat change in T-wave morphology, amplitude, and/or polarity on the ECG, often heralds the development ...
Mechanisms Related to the Cardioprotective Effects of Protein Kinase C ...
Naunyn-Schmiedebergs Archives of Pharmacology (2008)
The role of protein kinase C epsilon (PKC epsilon) in polymorphonuclear leukocyte (PMN)-induced myocardial ischemia/reperfusion (MI/R) injury and novel-related mechanisms, ...
Protein Kinase C BetaII Peptide Inhibitor Exerts Cardioprotective Effects in ...
The Journal of Pharmacology and Experimental Therapeutics (2005)
Ischemia followed by reperfusion (I/R) in the presence of polymorphonuclear leukocytes (PMNs) results in a marked cardiac contractile dysfunction. A ...
Protein Kinase C-Zeta Inhibition Exerts Cardioprotective Effects in Ischemia-Reperfusion Injury
American Journal of Physiology-Heart & Circulatory Physiology (2005)
Ischemia followed by reperfusion (I/R) in the presence of polymorphonuclear leukocytes (PMNs) results in marked cardiac contractile dysfunction. A cell-permeable ...
Rosuvastatin, a new HMG-CoA reductase inhibitor, protects ischemic reperfused myocardium ...
Journal of cardiovascular pharmacology (2003)
The 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) have been shown to upregulate endothelial nitric oxide synthase in isolated endothelial cells ...