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Article
Gö 6983 Exerts Cardioprotective Effects in Myocardial Ischemia/Reperfusion
Journal of cardiovascular pharmacology
  • Ellen E. Peterman
  • Philip Taormina, II
  • Margaret Harvey
  • Lindon Young, Philadelphia College of Osteopathic Medicine
Document Type
Article
Publication Date
1-1-2004
Disciplines
Abstract
Ischemia followed by reperfusion (I/R) in the presence of polymorphonuclear leukocytes (PMNs) results in cardiac contractile dysfunction. Inhibiting protein kinase C (PKC) inhibits the release of superoxide from PMNs. The compound Gö 6983 is an inhibitor of all five PKC isoforms present in PMNs. Therefore, we hypothesized that Gö 6983 could attenuate PMN-induced cardiac dysfunction by suppression of superoxide production from PMNs. We studied isolated rat hearts following ischemia (20 minutes) and reperfusion (45 minutes) infused with activated PMNs. In hearts reperfused with PMNs and Gö 6983 (100 nM, n = 7), left ventricular developed pressure (LVDP) and the rate of LVDP (+dP/dtmax recovered to 89 ± 7% and 74 ± 2% of baseline values, respectively, at 45 minutes postreperfusion compared with I/R hearts (n = 9) receiving PMNs alone, which only recovered to 55 ± 3% and 45 ± 5% of baseline values for LVDP and +dP/dt max, respectively (P < 0.01). Gö 6983 (100 nM) significantly reduced PMN adherence to the endothelium and infiltration into the myocardium compared with I/R + PMN hearts (P < 0.01), and significantly inhibited superoxide release from PMNs by 90 ± 2% (P < 0.01). In the presence of PMNs, Gö 6983 attenuated post-I/R cardiac contractile dysfunction, which may be related in part to decreased superoxide production.
Comments

This article was published in Journal of cardiovascular pharmacology, Volume 43, Issue 5, Pages 645-656.

The published version is available at http://dx.doi.org/10.1097/00005344-200405000-00006.

Copyright © 2004 LWW, Inc.

Citation Information
Ellen E. Peterman, Philip Taormina, Margaret Harvey and Lindon Young. "Gö 6983 Exerts Cardioprotective Effects in Myocardial Ischemia/Reperfusion" Journal of cardiovascular pharmacology Vol. 43 Iss. 5 (2004) p. 645 - 656
Available at: http://works.bepress.com/lindon_young/26/