Dr. Braun is currently focused on understanding how exercise, dietary energy/composition and/or pharmacological agents interact to mediate insulin resistance and the risk for Type-2 diabetes. The American Diabetes Association is our major source of funding for work on how the combination of exercise and/or the drug metformin impact glucose metabolism and insulin sensitivity at the cellular and whole-body levels. We also use stable isotope tracers to measure the regulation of substrate kinetics during exercise. Recent studies include the effects of concurrent energy surplus and exercise on insulin sensitivity, the net impact of high body fat and high cardiorespiratory fitness in women, and the utility of alternative carbohydrates to maintain optimal blood glucose control in humans with Type-2 diabetes.
Articles
The effect of carbohydrate availability following exercise on whole body insulin action, Applied Physiology, Nutrition, and Metabolism (2008)
One bout of exercise enhances insulin-stimulated glucose uptake (insulin action), but the effect is blunted...
Impact of metformin on peak aerobic capacity, Applied Physiology, Nutrition, and Metabolism (2008)
Individually, exercise and the drug metformin have been shown to prevent or delay type 2...
Effect of timing of energy/carbohydrate replacement on post-exercise insulin action, Applied Physiology, Nutrition, and Metabolism (2007)
The nutritional environment surrounding an exercise bout modulates post-exercise insulin action. The purpose of this...
Effect of high cardiorespiratory fitness and high body fat on insulin resistance, Medicine & Science in Sports & Exercise (2006)
PURPOSE: High cardiorespiratory fitness (CRF) dramatically lowers risk for cardiometabolic disease in overweight and obese...
Effect of Prior Exercise on Insulin Action in African-American Women, Journal of the National Medical Association (2006)
African Americans are more insulin resistant than Caucasians. A single bout of moderate-intensity exercise reduces...