Hussam A. Yacoub, DO, MS Physician Disciplines Medicine and Health Sciences Neurology Research Interests 7/99-8/01 Thesis Research: Laboratory of Molecular Pharmacology, Department of Physiology and Pharmacology, MCP Hahnemann University School of Medicine, Philadelphia PA. • Thesis Objectives: To investigate molecular mechanisms mediating desensitization of the G protein coupled A1-Adenosine receptor in the brain and aged heart, and to determine whether such alterations contribute to tissue vulnerability during ischemic insult. 8/97-6/99 Research Rotations at MCP Hahnemann University School of Medicine, Philadelphia, PA. • Center for Gene Therapy: Investigated the effect of tyrosine hydroxylase transfected primary rat astrocyte cultures on Parkinson’s disease rat models. • Department of Pharmacology & Physiology: Examined the effect of several pharmacological agents norepinephrine release in prepared young and aged rat heart synaptosomes. • Department of Neurobiology/Anatomy: Investigated the involvement of semaphorines in mediating growth of cerebellar neurite explants from the developing mouse brain. Research Assistant at Lehigh University, Bethlehem, PA. •Thesis Objectives: Prepared organic compounds in an organic synthesis laboratory. Overall goal was to isolate an anion transport protein found in proximal convoluted tubule cells of rat kidney nephron.
