Article
Large Animal Recovery following Total Liquid Ventilation (preliminary data)
ASAIO Journal
(2006)
Abstract
Objective of this study is to extubate and recover a normal sheep to spontaneous, room air breathing following total liquid ventilation (TLV). Three sheep weighing 27–29 kg underwent orotracheal intubation followed by arterial and Swan-Ganz catheters placed for hemodynamic monitoring. Total liquid ventilation was initiated by instilling 30 ml/kg of preoxygenated perfluorocarbon (FC77) and using a tidal volume, respiratory rate, and I:E ratio of 15 ml/kg, 5 cycles/min, and 1:2, respectively. TLV was performed for 3 hours, followed by transition into partial liquid ventilation by simply positioning the animal in a prone position and switching to conventional mechanical ventilation (CMV). The sheep were weaned from CMV, extubated and recovered to spontaneous breathing of room air for 60–90 minutes. All three sheep had stable hemodynamics and gas exchange (Figure 1) during the course of the entire study. They recovered to spontaneous breathing of room air and were able to stand during the recovery period. No complications or prolonged need of supplemental oxygen was noted. These results demonstrate the safety and effectiveness of TLV in normal animal recovery. Further studies are needed to demonstrate the recovery in a large animal lung-injury model on long-term TLV.
Keywords
- Total Liquid Ventilation
Disciplines
Publication Date
March, 2006
Citation Information
Rupa Seetharamaiah. "Large Animal Recovery following Total Liquid Ventilation (preliminary data)" ASAIO Journal Vol. 52 Iss. 2 (2006) p. 67A Available at: http://works.bepress.com/rupa-seetharamaiah/16/