Professor, Department of Veterinary and Animal Sciences, College of Natural Sciences
My long term goal is to understand how the sperm acquire fertilizing capacity at the molecular level. In particular, I am focusing in several basic questions that arise from the capacitation model in the figure such as:
1. Which are the protein substrates for tyrosine phosphorylation and how are they involved in the capacitation process?
2. Which are the tyrosine kinase/s and/or phosphotyrosine phosphatases responsible for the increase in protein tyrosine phosphorylation observed during capacitation?
3. How capacitation and the capacitation-associated hyperpolarization are regulated by components of the capacitation medium?
4. How are changes in cAMP, protein tyrosine phosphorylation and hyperpolarization of the sperm plasma membrane integrated to regulate capacitation?
5. Where in the sperm do the changes in cAMP, protein tyrosine phosphorylation and hyperpolarization occur during capacitation?
6. How cholesterol removal affects signaling pathways during sperm capacitation?
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1. Which are the protein substrates for tyrosine phosphorylation and how are they involved in the capacitation process?
2. Which are the tyrosine kinase/s and/or phosphotyrosine phosphatases responsible for the increase in protein tyrosine phosphorylation observed during capacitation?
3. How capacitation and the capacitation-associated hyperpolarization are regulated by components of the capacitation medium?
4. How are changes in cAMP, protein tyrosine phosphorylation and hyperpolarization of the sperm plasma membrane integrated to regulate capacitation?
5. Where in the sperm do the changes in cAMP, protein tyrosine phosphorylation and hyperpolarization occur during capacitation?
6. How cholesterol removal affects signaling pathways during sperm capacitation?
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About Pablo E. Visconti
My long term goal is to understand how the sperm acquire fertilizing capacity at the molecular level. In particular, I am focusing in several basic questions that arise from the capacitation model in the figure such as:
1. Which are the protein substrates for tyrosine phosphorylation and how are they involved in the capacitation process?
2. Which are the tyrosine kinase/s and/or phosphotyrosine phosphatases responsible for the increase in protein tyrosine phosphorylation observed during capacitation?
3. How capacitation and the capacitation-associated hyperpolarization are regulated by components of the capacitation medium?
4. How are changes in cAMP, protein tyrosine phosphorylation and hyperpolarization of the sperm plasma membrane integrated to regulate capacitation?
5. Where in the sperm do the changes in cAMP, protein tyrosine phosphorylation and hyperpolarization occur during capacitation?
6. How cholesterol removal affects signaling pathways during sperm capacitation?
1. Which are the protein substrates for tyrosine phosphorylation and how are they involved in the capacitation process?
2. Which are the tyrosine kinase/s and/or phosphotyrosine phosphatases responsible for the increase in protein tyrosine phosphorylation observed during capacitation?
3. How capacitation and the capacitation-associated hyperpolarization are regulated by components of the capacitation medium?
4. How are changes in cAMP, protein tyrosine phosphorylation and hyperpolarization of the sperm plasma membrane integrated to regulate capacitation?
5. Where in the sperm do the changes in cAMP, protein tyrosine phosphorylation and hyperpolarization occur during capacitation?
6. How cholesterol removal affects signaling pathways during sperm capacitation?
| Present | Professor, Department of Veterinary and Animal Sciences, College of Natural Sciences, University of Massachusetts Amherst | |
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Disciplines
Research Interests
Honors and Awards
- Rockefeller Foundation Postdoctoral Fellow 1991-1995
- Rayard Storey Award 1999
Contact Information
427W Integrated Science Building
University of Massachusetts Amherst
Amherst MA, 01003
Tel:413-545-5565