For first-generation college students (FGCSs) reconsidering their majors and future occupations, career exploration can also elicit mental health concerns arising from the unique place these individuals hold in their families and the students’ reported reasons for attending college. This article provides career practitioners with a glimpse into the mental health concerns and familial issues that can arise for FGCSs during career exploration given the unique background of this population. Strategies for career practitioners to use while working with FGCSs will be discussed.