|Present||Associate Professor of Pharmaceutical Sciences, Cedarville University ‐ School of Pharmacy|
Honors and Awards
- Toxicological Highlight Manuscript for Toxicological Sciences - 2001
- Medicinal Biochemistry
- Clinical Toxicology
|PhD in Toxicology, University of Michigan|
|BS in Toxicology, Ashland University|
School of Pharmacy
Mitochondrial Dysfunction in Mechanisms of Ethanol Toxicity in the Spinal Neural Crest Faculty Dissertations (2001)
It was hypothesized that ethanol inhibits neural crest cell (NCC) migration and differentiation through induction of the mitochondrial permeability transition (MPT). Cultures of spinal NCCs contained mixtures of polarized and unpolarized mitochondria. Migration of NCCs ...
Book Chapters (3)
Journal Articles (18)
Assessment of the Effects of MPTP and Paraquat on Dopaminergic Neurons and Microglia in the Substantia Nigra Pars Compacta of C57BL/6 Mice PLoS One (2016)
The neurotoxicity of paraquat dichloride (PQ) was assessed in two inbred strains of 9- or 16-week old male C57BL/6 mice housed in two different laboratories and compared to the effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). PQ was ...
Dietary Administration of Paraquat for 13 Weeks Does Not Result in a Loss of Dopaminergic Neurons in the Substantia nigra of C57BL/6J Mice Journal of Regulatory Toxicology and Pharmacology (2014)
Several investigations have reported that mice administered paraquat dichloride (PQ·Cl2) by intraperitoneal injection exhibit a loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc). In this study, male and female C57BL/6J mice were ...
Loss of Leucine-rich Repeat Kinase 2 (LRRK2) in Rats Leads to Progressive Abnormal Phenotypes in Peripheral Organs PloS One (2013)
The objective of this study was to evaluate the pathology time course of the LRRK2 knockout rat model of Parkinson’s disease at 1-, 2-, 4-, 8-, 12-, and 16-months of age. The evaluation consisted of ...
Characterization of the T-dependent Antibody Response (TDAR) to Keyhole Limpet Hemocyanin (KLH) in the Gottingen Minipig Journal of Immunotoxicology (2013)
Recently, there has been a renewed interest in the use of the minipig as an alternative to dogs and non-human primates for conducting toxicological assessments in non-rodent species. Since the T-dependent antibody response (TDAR) is ...
Pharmacokinetic, Neurochemical, Stereological and Neuropathological Studies on the Potential Effects of Paraquat in the Substantia Nigra Pars Compacta and Striatum of Male C57BL/6J Mice NeuroToxicology (2013)
The pharmacokinetics and neurotoxicity of paraquat dichloride (PQ) were assessed following once weekly administration to C57BL/6J male mice by intraperitoneal injection for 1, 2 or 3 weeks at doses of 10, 15 or 25 mg/kg/week. ...
Cholinesterase Inhibition and Toxicokinetics in Immature and Adult Rats After Acute or Repeated Exposures to Chlorpyrifos or Chlorpyrifos–oxon Regulatory Toxicology and Pharmacology (2012)
The effect of age or dose regimen on cholinesterase inhibition (ChEI) from chlorpyrifos (CPF) or CPF–oxon (CPFO) was studied in Crl:CD(SD) rats. Rats were exposed to CPF by gavage in corn oil, rat milk (pups), ...
An Oral Developmental Neurotoxicity Study of Decabromodiphenyl Ether (DecaBDE) in Rats Birth Defects Research Part B: Developmental and Reproductive Toxicology (2011)
Decabromodiphenyl ether (DecaBDE; CASRN 1163-19-5) is a flame retardant used in a variety of manufactured products. A single oral dose of 20.1 mg/kg administered to mice on postnatal day 3 has been reported to alter ...
Effects of Dose, Administration Route and/or Vehicle on Decabromodiphenyl Ether (DecaBDE) Concentrations in Plasma of Maternal, Fetal and Neonatal Rats and in Milk of Maternal Rats Drug Metabolism and Disposition (2010)
The effects of route and vehicle on blood and milk levels of decabromodiphenyl ether (DecaBDE; CASRN 1163-19-5) were investigated in the rat to assist in the design and conduct of a developmental neurotoxicity study. Blood ...
Developmental Neurotoxicity Study of Dietary Bisphenol A in Sprague-Dawley Rats Toxicological Sciences (2010)
This study was conducted to determine the potential of bisphenol A (BPA) to induce functional and/or morphological effects to the nervous system of F1offspring from dietary exposure during gestation and lactation according to the Organization ...
28-Day Oral (Gavage) Toxicity Studies of Green Tea Catechins Prepared for Beverages in Rats Food and Chemical Toxicology (2008)
The beneficial health effects associated with drinking green tea are widely considered to be due primarily to tea catechins. Heat treatment of marketed green tea beverages for sterilization causes epimerization and/or polymerization of tea catechins. ...
Inhalation Developmental Neurotoxicity Study of Ethylbenzene in Crl-CD Rats Birth Defects Research Part B: Developmental and Reproductive Toxicology (2007)
This study was conducted to evaluate the potential adverse effects of whole-body inhalation exposure of F0 and F1 parental animals from a 2-generation reproduction study of ethylbenzene on nervous system functional and/or morphologic end points ...
Developmental Neurotoxicity Study of Styrene by Inhalation in Crl-CD Rats Birth Defects Research Part B: Developmental and Reproductive Toxicology (2005)
This study was conducted to assess potential adverse functional and/or morphological effects of styrene on the neurological system in the F2 offspring following F0 and F1 generation whole-body inhalation exposures. Four groups of male and ...
1,3-Dinitrobenzene Inhibits Mitochondrial Complex II in Rat and Mouse Brainstem and Brainstem and Cortical Astrocytes NeuroToxicology (2003)
1,3-Dinitrobenzene (DNB) produces edematous, glio-vascular lesions that are initially confined to brainstem nuclei with high energy requirements in rats and mice. Perturbation of energy producing processes in the cell is known to induce formation of ...
Spatial Glutathione and Cysteine Distribution and Chemical Modulation in the Early Organogenesis Stage Rat Conceptus In Utero Toxicological Sciences (2001)
Glutathione (GSH), cysteine, and other low-molecular-weight thiols (LMWT) play a vital role in the detoxication of xenobiotics and endogenous chemicals. Differential alterations of LMWT status in various cell types of the developing embryo may underlie ...
Comparison of In Vitro and In Utero Ethanol Exposure on Indices of Oxidative Stress In Vitro and Moelcular Toxicology (2000)
Prenatal ethanol exposure produces neural tube defects and growth retardation in experimental animals. Because ethanol's teratogenic effects may involve oxidative stress and effects may differ in vitro and in utero, glutathione, cysteine and ATP were ...
Effects of 3,3’Iminodipropionitrile (IDPN) on Behavior and LDH Activity in Rats BIOS (1996)
3,3′-Iminodipropionitrile (IDPN) is a synthetic neurotoxicant. The purpose of this study was to observe the effects of IDPN on rat behavior and LDH activity in brain and spinal cord homogenates. One group of rats was ...