Article
Influence of Deliverable Form of Dietary Vitamin D3 on the Immune Response in Late-Lactating Dairy Goatse
Dairy
(2024)
Abstract
Mastitis-causing bacteria can establish persistent infections in the mammary glands of
commercially important dairy animals despite the presence of strong specific humoral and cellular
immune mechanisms. We investigated the effect of vitamin D3 in the diet at a set level, but in
two different forms (i.e., unencapsulated and encapsulated by complex coacervation with sulfursaturated
bovine lactoferrin-alginate using microbial transglutaminase-catalyzed crosslinking) on
the immune response in late-lactating dairy goats. Dairy goats (n = 18) were randomly assigned
to three experimental groups (n = 6). Dairy goats were orally administered 0.35 mg of vitamin
D3/day in the unencapsulated form and 0.35 mg of vitamin D3/day in the encapsulated powder
form. Another group received the basal diet. The experimental period lasted 6 weeks. The blood
serum concentrations of 25-hydroxyvitamin D3 [25-(OH)-D3], lactoferrin, immunoglobulin A (IgA),
and interferon-gamma (INF-γ) were measured. There were major differences in these parameters
between dietary groups. However, the delivery of vitamin D3 in the encapsulated powder form to
dairy goats resulted in a marked increase in 25-(OH)-D3 concentration in serum, while the serum
level of lactoferrin also increased. Alternatively, the serum levels of IgA and the immunomodulatory
cytokine INF-γ were elevated following supplementation with the encapsulated vitamin D3. The
observed effects suggest that the deliverable form of dietary vitamin D3 results in differences in the
immune response in late-lactating dairy goats.
Keywords
- Bovine lactoferrin,
- complex coacervation,
- dairy goats,
- encapsulation,
- immune response
Disciplines
Publication Date
Spring May 22, 2024
DOI
https://doi.org/10.3390/dairy5020025
Citation Information
Adela Mora-Gutierrez, Maryuri Nunez de Gonzalez, Selamawit Woldesenbet, Rahmat Attaie, et al.. "Influence of Deliverable Form of Dietary Vitamin D3 on the Immune Response in Late-Lactating Dairy Goatse" Dairy Vol. 5 Iss. 2 (2024) p. 308 - 315 Available at: http://works.bepress.com/maryuri-nunezdegonzalez/38/