The regular consumption of whole grains and their products may reduce the risk of chronic diseases, such as cardiovascular diseases, type II diabetes, and several forms of cancer. The objective of this study was to evaluate the bioactive compounds content in wholemeals and brans of rice (Cimarron, FONAIAP 1 and Zeta 15 varieties), such as: total dietary fiber (FDT), determined by gravimetric-enzymatic method; trypsin inhibitors (IT), phytic acid (AF), and condensed tannins (TC) contents, all of them determined by colorimetric methods. Significant differences (p < 0.05) for bioactive compounds content were found between brans and wholemeals. It was found that rice brans are good sources of FDT, AF, and TC. The highest content of FDT was observed in the Cimarron variety as bran (40.61 ± 0.10%) as well as wholemeal (14.04 ± 0.12%); while FONAIAP 1 exhibited the lowest content in bran (33.67 ± 0.64%) and wholemeal (11.44 ± 0.24%.). The IT in rice wholemeal and bran ranked from 5.70 ± 0.02 to 6.35 ± 0.35 mg/g in all varieties, with the exception of wholemeal from Zeta 15 variety (3.72 ± 0.04 mg/g). In the brans, AF and TC concentrations showed significantly higher values with respect to wholemeals. The findings showed that wholemeals and brans of rice analyzed in this study may provide important dietary bioactive compounds (FDT, IT, AF and TC) of great significance for health. The brans showed to be a fraction of the rice with high concentration of FDT, AF and TC.