About Lubov Nathanson
I earned my PhD degree in Molecular Biology and Biochemistry from the prestigious Weizmann Institute of Science, Israel. My Ph.D. and postdoctoral experience allowed me to gain better understanding of cellular processes. As a Manager and later Director of the Gene Expression and Microarray Core (2004 - 2010), I gained extensive hands-on experience of sample processing for microarray, Nanostring and NextGen sequencing analyses. As part of the Bioinformatics group (2010-2012) I used and evaluated many different bioinformatics software tools. I also gained experience in analyzing large genomics datasets as well as conducting systems biology analyses. Thus, I have combined expertise in bioinformatics, Molecular Biology, Biochemistry and Systems Biology. Much of my academic work in recent years involved analyses of gene expression data from Nanostring, microarrays and RNA-seq (see publications).
|Present||Assistant Professor, Nova Southeastern University ‐ Halmos College of Natural Sciences and Oceanography, Department of Biological Sciences|
|2000||Postdoctoral -- Biochemistry, University of Miami|
|1998||Ph.D. -- Molecular Biology & Biochemistry, Weizmann Institute of Science|
|1985||M.S. -- Biology / Biophysics, Moscow State University|
Integrated whole transcriptome and DNA methylation analysis identifies gene networks specific to late-onset Alzheimer’s disease Journal of Alzheimers Disease (2015)
Previous transcriptome studies observed disrupted cellular processes in late-onset Alzheimer's disease (LOAD), yet it is unclear whether these changes are specific to LOAD, or are common to general neurodegeneration. In this study, we address this ...
Using gene expression signatures to identify novel treatment strategies in gulf war illness BMC medical genomics (2015)
Background Gulf War Illness (GWI) is a complex multi-symptom disorder that affects up to one in three veterans of this 1991 conflict and for which no effective treatment has been found. Discovering novel treatment strategies ...
Cardiac performance, biomarkers and gene expression studies in previously sedentary men participating in half-marathon training BMC Sports Science, Medicine and Rehabilitation (2014)
BACKGROUND: The mechanisms through which exercise reduces cardiovascular disease are not fully understood. We used echocardiograms, cardiac biomarkers and gene expression to investigate cardiovascular effects associated with exercise training. METHODS: Nineteen sedentary men (22-37 years) ...
In vitro global gene expression analyses support the ethnopharmacological use of Achyranthes aspera Evidence-Based Complementary and Alternative Medicine (2013)
Achyranthes aspera (family Amaranthaceae) is known for its anticancer properties. We have systematically validated the in vitro and in vivo anticancer properties of this plant. However, we do not know its mode of action. Global ...
Copy number variation in pediatric multiple sclerosis Multiple Sclerosis (2013)
BACKGROUND: Pediatric onset multiple sclerosis (MS) accounts for 2-4% of all MS. It is unknown whether the disease shares the same underlying pathophysiology found in adult patients or an extreme early onset phenotype triggered by ...
Genomic Signatures of a Global Fitness Index in a Multi-Ethnic Cohort of Women Annals of Human Genetics (2013)
The rates of obesity and sedentary lifestyle are on a dramatic incline, with associated detrimental health effects among women in particular. Although exercise prescriptions are useful for overcoming these problems, success can be hampered by ...
Retinoblastoma treatment: impact of the glycolytic inhibitor 2-deoxy-d-glucose on molecular genomics expression in LHBETATAG retinal tumors Clinical Opthalmology (2012)
Purpose: The purpose of this study was to evaluate the effect of 2-deoxy-D-glucose (2-DG) on the spatial distribution of the genetic expression of key elements involved in angiogenesis, hypoxia, cellular metabolism, and apoptosis in LHBETATAG ...
Evidence of novel finescale structural variation at autism spectrum disorder candidate loci Molecular Autism (2012)
Background: Autism spectrum disorders (ASD) represent a group of neurodevelopmental disorders characterized by a core set of social-communicative and behavioral impairments. Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the brain, acting primarily via ...
Alternative RNA splicing and gene expression profiles in early stage Hypoplastic Left Heart Syndrome PLOS One (2012)
Hypoplastic Left Heart Syndrome (HLHS) is a congenital defect characterized by underdevelopment of the left ventricle and pathological compensation of the right ventricle. If untreated, HLHS is invariably lethal due to the extensive increase in ...
Novel male-biased expression in paralogs of the aphid slimfast nutrient amino acid transporter expansion BMC Evolutionary Biology (2011)
BACKGROUND: A major goal of molecular evolutionary biology is to understand the fate and consequences of duplicated genes. In this context, aphids are intriguing because the newly sequenced pea aphid genome harbors an extraordinary number ...
Regional and temporal differences in gene expression of LH(BETA)T(AG) retinoblastoma tumors Investigative Ophthalmology & Visual Science (2011)
PURPOSE: The purpose of this study was to evaluate by microarray the hypothesis that LH(BETA)T(AG) retinoblastoma tumors exhibit regional and temporal variations in gene expression. METHODS: LH(BETA)T(AG) mice aged 12, 16, and 20 weeks were ...