My research interests including the roles of renin-angiotensin system (RAS) pathways, stem cells, and extracellular microvesicles (MVs)/exosomes (EXs) in hypertension and diabetes related vascular complications with focus on ischemic and hemorrhagic stroke. Several signal pathways such as PI3K/Akt/eNOS and NFƙB, and microRNA mechanisms are actively investigated. My research approaches include using transgenic mouse models in combination with animal surgeries, such as telemetric probe implantation for recording blood pressure and heart rate, and minipump/microinjection for chronic/acute drug administration, middle cerebral artery occlusion (MCAO) for inducing ischemic stroke. Recently, I have applied several novel approaches for analysis of MVs/EXs, including flow cytometry, mass spectrum and RNA sequencing, nanosight tracking analysis (NTA), etc.