Assistant Professor of Genetics, Development, and Cell Biology
The goal of my laboratory is to develop a systems level understanding of the development and degeneration of neurons. Single cell transcriptomics in conjunction with gain and loss of function experiments are utilized to identify the gene expression networks responsible for generating neuronal diversity in the developing mouse, zebrafish and chicken retina, specifically among the retinal ganglion cells. These data can be used to enhance the efficiency with which ganglion cells are generated for potential uses in therapies for optic neuropathies such as glaucoma. A second avenue of research in the lab uses the same single cell technology to examine motor neurons that are resistant to the disease-causing mechanisms of Amyotrophic Lateral Sclerosis (ALS). These experiments will identify new potential drug targets for intervention in ALS patients.
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About Jeffrey Trimarchi
The goal of my laboratory is to develop a systems level understanding of the development and degeneration of neurons. Single cell transcriptomics in conjunction with gain and loss of function experiments are utilized to identify the gene expression networks responsible for generating neuronal diversity in the developing mouse, zebrafish and chicken retina, specifically among the retinal ganglion cells. These data can be used to enhance the efficiency with which ganglion cells are generated for potential uses in therapies for optic neuropathies such as glaucoma. A second avenue of research in the lab uses the same single cell technology to examine motor neurons that are resistant to the disease-causing mechanisms of Amyotrophic Lateral Sclerosis (ALS). These experiments will identify new potential drug targets for intervention in ALS patients.
| Present | Assistant Professor, Iowa State University ‐ Department of Genetics, Development and Cell Biology | |
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Disciplines
Contact Information
2114 Molecular Bio
2437 Pammel Dr
Ames, IA 50011-1079
515-294-7059
Email: