Buprenorphine- Naloxone is a promising medication in the management of opioid dependence. A retrospective chart review of 69 opioid dependent patients treated with Buprenorphine- Naloxone was conducted. The mean age was 36. 53.6% women, 1.4% Asian, 4.3% Black and 87.0% Caucasian. 75.4% had high school or higher education. 65.2% were using prescriptional opioid medications and 34.8% illicit opioids. 81.2% were polysubstance users. Buprenorphine- Naloxone was well tolerated by 66.7% of patients. 18.8% had transient and 11.6% had persistent adverse effects. Subsequent data analysis will identify any statistical correlation in retention and relapse rates at 1 month and 1 year, also any outcome differences in patients by age, gender, duration of opioid use, drug of choice, history of polysubstance use and initial COWS scores.