SelectedWorks - J. Ashot Kozak

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Selected Works of J. Ashot Kozak

Associate Professor, Neuroscience, Cell Biology & Physiology

Research Interests:
Cation channels expressed in leukocytes; Transient Receptor Potential (TRP) channels; ion channels involved in nociception.
Teaching:

Human Physiology (BMS 8620): Immunity, Blood, Molecular Endocrinology

Neuroscience and Physiology (BMS 8750): Pain and Ion Channels, Control of Intracellular Calcium

Endocrine (SMD 561): Physiology of Parathyroid Glands

Ion Channels (BMS 8530): TRP channels

Works
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About J. Ashot Kozak

Research Interests:
Cation channels expressed in leukocytes; Transient Receptor Potential (TRP) channels; ion channels involved in nociception.
Teaching:

Human Physiology (BMS 8620): Immunity, Blood, Molecular Endocrinology

Neuroscience and Physiology (BMS 8750): Pain and Ion Channels, Control of Intracellular Calcium

Endocrine (SMD 561): Physiology of Parathyroid Glands

Ion Channels (BMS 8530): TRP channels

Present	Associate Professor, Wright State University ‐ Neuroscience, Cell Biology & Physiology
Institution Organization Position Type Position Title Time Period to Options Current Position Affiliate my profile with this Institution

Life Sciences, Neuroscience and Neurobiology, Physiology, Medicine and Health Sciences, Medical Sciences, Medical Cell Biology, Medical Physiology, Neurosciences, and Physiological Processes

Cation Channels Expressed in Leukocytes, Transient Receptor Potential (TRP) Channels, and Ion Channels Involved in Nociception

Present	Member, BMS PhD Program Curriculum Committee
Present	Faculty Advisor, BMSSA (BMS PhD Student Association)
Present	Member, BSoM Research Committee
Present	Member, CoSM IT Committee
Present	Director, NCBP Departmental Seminar Series

Human Physiology (BMS 8620) Co-Director: Immunity, Blood, Molecular Endocrinology, Calcium regulation
Neuroscience and Physiology (BMS 8750): Pain and Ion Channels, Control of Intracellular Calcium
Endocrine (SMD 561): Physiology of Parathyroid Glands
Ion Channels (BMS 8530): TRP channels
Physiology Seminar (P&N 8000)
Anatomy Seminar (ANT 7900)

	Ph.D., Icahn School of Medicine at Mount Sinai
Institution Organization Student Type Student Title Degree Time Period to Options Currently enrolled Affiliate my profile with this Institution

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Biological Sciences Bldg II 251A

3640 Colonel Glenn Hwy

Dayton, OH 45435-0001

(937) 775-4514

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Articles (42)

Suppression of Store-operated Calcium Entry Channels and Cytokine Release by ...

Function (2022)

TRPM7 Kinase Inactivation Results in Macrophage Alkalinization and Increased Phagocytic ...

Biophysical Journal (2022)

Jananie Rockwood, Pavani Beesetty, Taku Kaitsuka, Masayuki Matsushita, et al.

Transient receptor potential melastatin 7 (TRPM7) is a unique protein that is both an ion channel and a cytosolic protein ...

NSAIDs Naproxen, Ibuprofen, Salicylate, and Aspirin Inhibit TRPM7 Channels by ...

Frontiers in Physiology (2021)

Rikki Chokshi, Orville Bennett, Tetyana Zhelay and J. Ashot Kozak

Non-steroidal anti-inflammatory drugs (NSAIDs) are used for relieving pain and inflammation accompanying numerous disease states. The primary therapeutic mechanism of ...

TRPM7 Permeant Divalent Metal Cytotoxicity During Magnesium Depletion and Loading

Biophysical Journal (2021)

Alayna A. Mellott, Jananie Rockwood, Charles T. Luu and J. Ashot Kozak

Phagocytic Activity of Splenic Macrophages Is Enhanced and Accompanied by ...

The FEBS Journal (2020)

Pavani Beesetty, Jananie Rockwood, Taku Kaitsuka, Tetyana Zhelay, et al.

Transient receptor potential melastatin 7 (TRPM7) is a unique protein functioning as a cation channel as well as a serine/threonine ...

TRPM7 Channel Activity in Jurkat T Lymphocytes During Magnesium Depletion ...

Pflugers Archiv : European journal of physiology (2020)

Alayna Mellott, Jananie Rockwood, Tetyana Zhelay, Charles Tuan Luu, et al.

TRPM7 is a cation channel-protein kinase highly expressed in T lymphocytes and other immune cells. It has been proposed to ...

Effects of TRPM7 Kinase Inactivation in Macrophages

Biophysical Journal (2020)

Jananie Rockwood, Pavani Beesetty, Masayuki Matsushita and J. Ashot Kozak

Transient Receptor Potential Melastatin 7 (TRPM7) is a unique protein possessing ion channel and serine/threonine kinase domains and functionality. Our ...

Initial Characterization of the Indole-3-Carboxamide Bic-154 as a Fast Onset ...

Biophysical Journal (2019)

Tetyana Zhelay, Kalina Szteyn, Elisa Liardo, Jae Eun Cheong, et al.

Calcium ion elevations are required for human T-lymphocyte proliferation in response to antigen recognition by a T-cell receptor. Calcium influx ...

Depletion of Plasma Membrane–Associated Phosphoinositides Mimics Inhibition of TRPM7 ...

Journal of Biological Chemistry (2018)

Tetyana Zhelay, Krystyna Blanka Wieczerzak, Pavani Beesetty, Gerald M. Alter, et al.

Transient receptor potential cation channel subfamily M member 7 (TRPM7) is an ion channel/protein kinase belonging to the TRP melastatin ...

Inactivation of TRPM7 Kinase in Mice Results in Enlarged Spleens ...

Scientific Reports (2018)

Pavani Beesetty, Krystyna Blanka Wieczerzak, Jennifer Gibson, Taku Kaitsuka, et al.

T lymphocytes enlarge (blast) and proliferate in response to antigens in a multistep program that involves obligatory cytosolic calcium elevations. ...

TRPM7 Current Inactivation: Evidence for Inside-Out Signaling

Biophysical Journal (2018)

Tetyana Zhelay and J. Ashot Kozak

TRPM7 channels conduct metal cations such as Na+, K+, Ca2+ and Mg2+. In the presence of external Ca2+/Mg2+ TRPM7 has ...

The Neuronal K+CL− Co-Transporter 2 (Slc12a5) Modulates Insulin Secretion

Scientific Reports (2017)

Shams Kursan, Timothy S McMillen, Pavani Beesetty, Eduardo Dias-Junior, et al.

Intracellular chloride concentration ([Cl−]i) in pancreatic β-cells is kept above electrochemical equilibrium due to the predominant functional presence of Cl− ...

Regulation of TRPM7 by Cytosolic Mg2+ and pH: Insights from ...

Biophysical Journal (2017)

Pavani Beesetty, Krystyna Blanka Wieczerzak, Tatyana Zhelay, Taku Kaitsuka, et al.

TRPM7 is an ion channel/protein kinase belonging to TRP melastatin and eEF2 kinase families. Under physiological conditions, most native TRPM7 ...

Mitogenic Activation and Proliferation of T Lymphocytes in TRPM7 Kinase-Dead ...

Biophysical Journal (2016)

Pavani Beesetty, Masayuki Matsushita and J. Ashot Kozak

Calcium and magnesium ions have been implicated in T lymphocyte proliferation in response to antigen recognition. Specifically, it is believed ...

Responses of Cortical Extrastriate Area 21a Neurons Specialized in Motion ...

Neurophysiology (2015)

D. K. Khachvankian, H. R. Aslanian, Bella A. Harutiunian-Kozak, A. L. Ghazaryan, et al.

According to a generally accepted concept, the stationary structure of the receptive field of a visually sensitive central neuron predetermines ...

2-Aminoethyl Diphenyl Borinate (2-APB) Inhibits TRPM7 Channels Through an Intracellular ...

Channels (2012)

Rikki Chokshi, Petronilla Fruasaha and J. Ashot Kozak

2-APB is a widely used compound in ion channel research. It affects numerous channels including inositol 1,4,5-trisphosphate receptors, store-operated calcium ...

Spatial Infrastructure of Receptive Fields and Responses to Moving Stimuli ...

Neurophysiology (2012)

J. Ashot Kozak, D. K. Khachvankyan, A. L. Ghazaryan, A. B. Sharanbekyan, et al.

The structure of receptive fields (RFs) of visually sensitive neurons has been shown in numerous studies to be the main ...

Sensitivity of TRPM7 Channels to Mg2+ Characterized in Cell-Free Patches ...

American Journal of Physiology - Cell Physiology (2012)

Rikki Chokshi, Masayuki Matsushita and J. Ashot Kozak

Transient receptor potential melastatin 7 (TRPM7) channels were originally identified electrophysiologically when depletion of cytosolic Mg2+ resulted in the gradual ...

Effect of Synthetic Aβ Peptide Oligomers and Fluorinated Solvents on ...

PLOS ONE (2012)

Maria I. Lioudyno, Matteo Broccio, Yuri Sokolov, Suhail Rasool, et al.

The impact of synthetic amyloid β (1–42) (Aβ1–42) oligomers on biophysical properties of voltage-gated potassium channels Kv 1.3 and lipid ...

Detailed Examination of Mg2+ and pH Sensitivity of Human TRPM7 ...

American Journal of Physiology - Cell Physiology (2012)

Rikki Chokshi, Masayuki Matsushita and J. Ashot Kozak

TRPM7 channel kinase is a protein highly expressed in cells of hematopoietic lineage, such as lymphocytes. Studies performed in native ...

Dynamic Spatial Organization of Receptive Fields of Neurons in the ...

Neurophysiology (2010)

Bella A. Harutiunian-Kozak, D. K. Khachvankyan, G. G. Grigoryan, J. Ashot Kozak, et al.

We studied changes in the spatial parameters of receptive fields (RFs) of visually sensitive neurons in the associative area 21a ...

Store-Dependent and -Independent Modes Regulating Ca2+ Release-Activated Ca2+ Channel Activity ...

The Journal of Biological Chemistry (2008)

Shenyuan L. Zhang, J. Ashot Kozak, Weihua Jiang, Andriy V. Yeromin, et al.

We evaluated currents induced by expression of human homologs of Orai together with STIM1 in human embryonic kidney cells. When ...

Orientation Sensitive Properties of Visually Driven Neurons in Extrastriate Area ...

Archives Italiennes de Biologie (2008)

Bella A. Harutiunian-Kozak, Gayane G. Grigorian, J. Ashot Kozak, A. B. Sharanbekyan, et al.

Orientation sensitive properties of extrastriate area 21a neurons were investigated. Special attention was paid to the qualitative characteristics of neuron ...

Spatial Organization of Receptive Fields and Dynamic Peculiarities of Neurons ...

Neurophysiology (2008)

D. K. Khachvankyan, J. Ashot Kozak, G. G. Grigoryan, A. B. Sharanbekyan, et al.

In neurons of the extrastriate area 21a of the cat cortex, we examined the mode of initiation and peculiarities of ...

Orai1 and STIM1 Move to the Immunological Synapse and Are ...

Proceedings of the National Academy of Sciences of the United States of America (2008)

Maria I. Lioudyno, J. Ashot Kozak, Aubin Penna, Olga Safrina, et al.

For efficient development of an immune response, T lymphocytes require long-lasting calcium influx through calcium release-activated calcium (CRAC) channels and ...