SelectedWorks - Heather L. Montie

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Selected Works of Heather L. Montie

Assistant Professor of Biochemistry and Molecular Biology, Dept. of Bio-Medical Sciences

Dr. Heather Montie leads research into the the androgen receptor function in Kennedy's Disease (SBMA) and Prostate Cancer. She teaches hemostatis, gastrointestinal physiology, and cerebellar anatomy and physiology in the College's DO and Biomedical Sciences programs.

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About Heather L. Montie

Dr. Heather Montie leads research into the the androgen receptor function in Kennedy's Disease (SBMA) and Prostate Cancer. She teaches hemostatis, gastrointestinal physiology, and cerebellar anatomy and physiology in the College's DO and Biomedical Sciences programs.

Present	Assistant Professor of Biochemistry and Molecular Biology, Dept. of Bio-Medical Sciences, Philadelphia College of Osteopathic Medicine ‐ Department of Bio-Medical Sciences
Institution Organization Position Type Position Title Time Period to Options Current Position Affiliate my profile with this Institution

Androgen Receptor Function, Kennedy's Disease (SBMA), Prostate Cancer, and Neurodegeneration

Prostate Cancer Foundation John A. Moran Young Investigator Award, 2012
Kennedy's Disease Association Research Award, 2013

Ph. 215-8716361

Fx. 215-871-6540

Email:

Scholarly Articles (12)

Identification Of Novel Polyglutamine-Expanded Aggregation Species In Spinal And Bulbar ...

Brain research (2015)

Tamar R Berger, Heather L. Montie, Pranav Jain, Justin Legleiter, et al.

Polyglutamine-repeat disorders are part of a larger family of neurodegenerative diseases characterized by protein misfolding and aggregation. In spinal and ...

Inhibition of Stat5a/b Enhances Proteasomal Degradation of Androgen Receptor ...

Molecular cancer therapeutics (2015)

David T Hoang, Lei Gu, Zhiyong Liao, Feng Shen, et al.

Although poorly understood, androgen receptor (AR) signaling is sustained despite treatment of prostate cancer with antiandrogens and potentially underlies development ...

Disrupting SUMOylation Enhances Transcriptional Function and Ameliorates Polyglutamine Androgen Receptor-Mediated ...

Journal of Clinical Investigation (2015)

Jason P. Chua, Satya L. Reddy, Zhigang Yu, Elisa Georgetti, et al.

Expansion of the polyglutamine (polyQ) tract within the androgen receptor (AR) causes neuromuscular degeneration in individuals with spinobulbar muscular atrophy ...

The Cell and Molecular Biology of Neurodegenerative Diseases: An Overview

Frontiers in Neurology (2013)

Heather L. Montie and Thomas M. Durcan

There is no abstract for this article.

SIRT1 modulates aggregation and toxicity through deacetylation of the androgen ...

Journal of Neuroscience (2011)

Heather L. Montie, Richard G. Pestell and Diane E. Merry

Posttranslational protein modifications can play a major role in disease pathogenesis; phosphorylation, sumoylation, and acetylation modulate the toxicity of a ...

An interdomain interaction of the androgen receptor is required for ...

Journal of Biological Chemistry (2010)

Christopher R. Orr, Heather L. Montie, Yuhong Liu, Elena Bolzoni, et al.

Polyglutamine expansion within the androgen receptor (AR) causes spinal and bulbar muscular atrophy (SBMA) and is associated with misfolded and ...

Autophagy and access: Understanding the role of androgen receptor subcellular ...

Autophagy (2009)

Heather L. Montie and Diane E. Merry

Ridding neurons of toxic misfolded proteins is a critical feature of many neurodegenerative diseases. We have recently reported that lack ...

Cytoplasmic retention of polyglutamine-expanded androgen receptor ameliorates disease via autophagy ...

Human molecular genetics (2009)

Heather L. Montie, Maria Cho, Latia Holder, Yuhong Liu, et al.

The nucleus is the primary site of protein aggregation in many polyglutamine diseases, suggesting a central role in pathogenesis. In ...

PERK is activated differentially in peripheral organs following cardiac arrest ...

Resuscitation (2005)

Heather L. Montie, Adam J. Haezebrouck, Jennifer C. Gutwald and Donald J. DeGracia

Visceral organs display differential sensitivity to ischemia and reperfusion injury, but the cellular mechanisms underlying these differential responses are not ...

Prolonged translation arrest in reperfused hippocampal cornu Ammonis 1 is ...

Neuroscience (2005)

Foaz Kayali, Heather L. Montie, J. A. Rafols and Donald J. DeGracia

Global brain ischemia and reperfusion cause phosphorylation of the alpha subunit of eukaryotic initiation factor 2a, a reversible event associated ...

Renal ischemia and reperfusion activates the eIF2 alpha kinase PERK

Biochimica et Biophysica Acta - Molecular Basis of Disease (2005)

Heather L. Montie, Foaz Kayali, Adam J. Haezebrouck, Noreen F. Rossi, et al.

Inhibition of protein synthesis occurs in the post-ischemic reperfused kidney but the molecular mechanism of renal translation arrest is unknown. ...

Cerebral ischemia and the unfolded protein response

Journal of neurochemistry (2004)

Donald J. DeGracia and Heather L. Montie

We review studies of endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) following cerebral ischemia and reperfusion (I/R). ...

Unpublished Paper

Determining the role of SIRT3 in spinal and bulbar muscular ...

CCDA (PCOM) (2014)

Heather L. Montie

Unpublished Paper

Investigating androgen receptor acetyltransferases as therapeutic targets for the treatment ...

Kennedy's Disease Association (2013)

Heather L. Montie

Unpublished Paper

Determining the role of androgen receptor acetylation in prostate cancer

Prostate Cancer Foundation (PCF) John A. Moran Young Investigator Award (2012)

Heather L. Montie

Unpublished Paper

A role for polyglutamine-expanded androgen receptor acetylation in spinal and ...

Kennedy's Disease Association (2008)

Heather L. Montie

Abstract 87: Targeting androgen receptor acetylation as a treatment for ...

Cancer research (2015)

Erin Heine, Diane E. Merry, Scott Dehm, Karen E. Knudsen, et al.

The goal of our studies is to determine the potential of targeting androgen receptor (AR) acetylation as a means to ...

Research Update Webinar

Kennedy's Disease Association (2014)

Heather L. Montie

Dr. Montie provides an introduction to her Kennedy's Disease Association-sponsored research for Association members. During this webinar, she provides a ...

Poster Presentations and Instructional Resources (4)

Determining the role of ARD1 in SBMA

Research Day (2015)

Abigail Lukasik, Erin Heine, Suzanna Hosein, Daniel Simpson, et al.

Determining the role of SIRT3 in spinal and bulbar muscular ...

Research Day (2015)

Daniel Simpson, Erin Heine and Heather Montie

Targeting androgen receptor acetylation as a treatment for castrate-resistant prostate ...

Research Day (2015)

Erin Heine, Diane E. Merry, Karen E. Knudsen and Heather L. Montie

The Role of Tip60 in SBMA

Research Day (2015)

Danielle Estrada, Erin Heine, Grant Ziegler, Kyle Brockman, et al.