Article
In vitro and in vivo activity of voriconazole and benznidazole combination on trypanosoma cruzi infection models
Acta Tropica
Document Type
Article
Publication Date
11-1-2020
URL with Digital Object Identifier
https://doi.org/10.1016/j.actatropica.2020.105606
Disciplines
Abstract
Combination therapy has been proposed as an ideal strategy to reduce drug toxicity and improve treatment efficacy in Chagas disease. Previously, we demonstrated potent in vivo anti-Trypanosoma cruzi activity of voriconazole. In this work, we aimed to study the synergistic effect of voriconazole (VCZ) and benznidazole (BZ) both in vitro and in vivo models of T. cruzi infection using the Tulahuen strain. Combining VCZ and BZ at fixed concentrations, the inhibitory concentration 50% (IC
Citation Information
Julián Ernesto Nicolás Gulin, Mackenzie Anne Eagleson, Rodrigo A López-Muñoz, María Elisa Solana, et al.. "In vitro and in vivo activity of voriconazole and benznidazole combination on trypanosoma cruzi infection models" Acta Tropica Vol. 211 (2020) p. 105606 Available at: http://works.bepress.com/facundo-garcia-bournissen/6/