Yuk-Ching Tse-Dinh
Director, Biomolecular Sciences Institute
Disciplines
- Biochemistry
Research Interests
- Development and implementation of cell based and enzyme based HTS assays to identify topoisomerase inhibitors
- SAR and optimization of topoisomerase inhibitor structures to generate specific antibacterial or anticancer drug leads
- Structural and biochemical studies of type IA topoisomerases to elucidate the mechanism of DNA manipulation and inhibitor action