Present | Director, Biomolecular Sciences Institute, Florida International University | |
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Present | Professor, Florida International University ‐ Department of Chemistry and Biochemistry | |
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Disciplines
Research Interests
Development and implementation of cell based and enzyme based HTS assays to identify topoisomerase inhibitors, SAR and optimization of topoisomerase inhibitor structures to generate specific antibacterial or anticancer drug leads, Structural and biochemical studies of type IA topoisomerases to elucidate the mechanism of DNA manipulation and inhibitor action, and Topoisomerase DNA-protein and protein-protein interactions during stress challenge from bacteria to mammalian systems