The Medical Apparel Development of Entrepreneurship course helps students: (a) understand fundamental product development concept and the process, (b) implement medical apparel development of entrepreneurship incorporating 3D printing, and (c) contribute to local community service centers for a service-learning practice task. The overall design concept and process will be useful in course content, including seven face-covering steps during the sixteenweek course. It is imperative for academia and industry to collaborate and contribute to finding an optimal face-covering prototype, created from suitable materials and elastics, which is washable, reusable, and hygienic better to understand the unique and straightforward pattern and design process. Furthermore, the proponent of academic service-learning provides not only real-world applications of classroom knowledge into a community setting, but also allows students to synthesize their face-coverings in more meaningful ways and adopt service-learning practices and lifestyles.