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About Duarte Freitas

Lithium salts are used in the treatment of bipolar disorder but the mechanism of action is poorly understood. We focus on two Mg2+-dependent protein systems, G-proteins and GSK-3β, which are key components of signal transduction pathways believed to malfunction in this mental illness. Our approach incorporates a battery of biophysical methods, including fluorescence and circular dichroism spectroscopy, isothermal titration calorimetry, and nuclear magnetic resonance and electron paramagnetic resonance. Using this methodology, we probe the Li+ and Mg2+ binding and competition properties, and the folding of these proteins.

Positions

Present Professor, Loyola University Chicago ‐ Department of Chemistry and Biochemistry
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Disciplines

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Research Works (10)