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About Dianzheng Zhang

Dr. Zhang’s general interest is the nutrient control of gene expression in health and disease. Particularly, he is interested in the regulation of gene expression by micronutrients, such as vitamins and minerals, as well as phytochemicals.

As living organisms, we continuously exchange chemical components with the environment; the exchange nutrients are implicated in the regulation of gene expression and cell fates, which ultimately confer life or death. With increasing knowledge of the importance of nutrition in our aging population, medicine is shifting its focus from treatment of acute diseases, to the prevention of cancer and chronic diseases. It has been estimated that thirty to fifty percent of all chronic diseases are preventable by attention to dietary factors.

Present research projects in his laboratory are focused on, but not limited to, the (1) molecular mechanisms of chemo-preventive effects of different phytochemicals, especially resveratrol, in prostate cancer development, (2) mechanisms of resveratrol effects on tensin expression and prostate cancer, and (3) the underlying molecular mechanisms of TMPRSS fusion with ETS transcriptional factors (ERG in particular) in cancer prevention and gene therapy.


Present Professor, Department of Biochemistry/Molecular Biology, Philadelphia College of Osteopathic Medicine Department of Bio-Medical Sciences
2008 Visiting Professor, Changsha Medical College
2007 Visiting Professor, Central South University ‐ Department of Biochemistry, College of Medicine


2010 - 2013 Modification of Resveratrol and Identification of More Potent Prostate Cancer Prevention Reagents
SynStar Inc.
2008 - 2010 Chromosomal Translocation-Induced Overexpression of ERG and Prostate Tumorigenesis
Christian R. Mary F. Lindback Foundation
2007 - 2010 Effects of Resveratrol in Aging and Prostate Cancer
Pennsylvania Department of Health, Bureau of Health Statistics and Research
2006 Formula Grant
2006 Resveratrol, Aging and Prostate Cancer
Center for Chronic Disorders of Aging (CCDA), PCOM
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Honors and Awards

  • 2006 Young Researcher Scholarship for AICR/WCRF International Research Conference on Food, Nutrition and Cancer
  • 2005 Outstanding Performance and Excellence in Scientific Presentation The 2005 Texas Chapter Annual Symposium
  • 2003 Award for Excellent Presentation of Research Society of Chinese Biochemists in America, Texas Chapter
  • 1990 Advanced Research Award Hunan province, P. R. China
  • 1989 Excellent Teaching Award Hunan Medical University, P. R. China



2001 PhD, University of Arizona ‐ Nutritional Science
1987 MS, Hunan Medical University ‐ Biochemistry
BS, Qufu Teaching University ‐ Chemistry

Contact Information

P: 215-871-6588


Scholarly Articles (107)