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About Dennis Peffley

After completing his PhD in genetics at the Pennsylvania State University, Dr. Peffley did postdoctoral training in molecular biology at the University of Colorado School of Medicine in Denver, Colorado. His first faculty position was in the Department of Pharmacology at the University of Tennessee Health Sciences Center in Memphis, Tennessee. At this institution, Dr. Peffley obtained his first NIH grant that focused on cholesterol synthesis.

Dr. Peffley then moved to the Rosalind Franklin School of Medicine in North Chicago, Illinois where he was promoted to associate professor in the Department of Pharmacology and Molecular Biology. His research interests moved from cholesterol research to the dietary prevention of cancer. To support this research, Dr. Peffley received an NIH grant from the National Cancer Institute.

A promotion to full professor lead Dr. Peffley to the Kansas City University of Medicine and Bioscience in the Department of Pharmacology. At this institution he continued his research in dietary prevention of cancer as well as teaching pharmacology, genetics and biochemistry. While in Kansas City, Dr. Peffley finished his Juris Doctor in law at the University of Missouri Kansas City School of Law. He has also served as founding faculty at two medical schools including Edward Via College of Osteopathic Medicine and The University of South Carolina School of Medicine Greenville.


Present Assistant Professor of Physiology and Pharmacology, Philadelphia College of Osteopathic Medicine Department of Bio-Medical Sciences


1999 - 2006 Modulation of Mevalonate Synthesis by Dietary Isoprenoids
National Cancer Institute - RO1 CA81756
Role: PI
2003 - 2004 Proteomic Analysis of Isoprenoid and Isoflavone-mediated Regulation of Cap-dependent and Cap-independent Protein Translation in Human Prostate Tumor Cells
Kansas City Area Life Sciences Institute Research Development Grant
Role: PI
1999 - 2000 Cancer Prevention by Isoprenoid Constituents of Plants
National Cancer Institute - RO1 CA73418
Role: Co-Investigator
1996 - 2000 Regulation of 3 Hydroxy 3 methylglutaryl Coenzyme A Reductase by Mevalonate and Oxysterols
American Heart Association (National Chapter) - HL 44006-O4S1
Role: PI
1996 - 1999 Dietary Isoprenoid Regulation of Growth Related Genes
National Cancer Institute - R03 CA72527
Role: PI
1990 - 1996 Regulation of HMG-CoA Reductase in Mammalian Cells
National Heart, Lung and Blood Institute - RO1 HL44006
Role: PI
1990 - 1993 Regulation of HMG-CoA Reductase by Oxysterols and Mevalonate
American Heart Association (National Chapter)
Role: PI
1989 - 1990 Regulation of HMG-CoA Reductase Gene Expression
American Health Assistance Foundation
Role: PI
1988 - 1990 The Translational Control of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase in Mammalian Cells
American Heart Association – Tennessee Affiliate
Role: PI
1988 - 1989 The Translational Control of HMG-CoA Reductase in Mammalian Cells
American Health Assistance Foundation
Role: PI
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Professional Service and Affiliations

Member, American Association of Biochemistry and Molecular Biology
Member, American Bar Association
Member, American Society for Pharmacology and Experimental Therapeutics
Member, District of Columbia Bar Association
Member, Missouri Bar Association
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Honors and Awards

  • Cora Louise Carson Award from the Tennessee Affiliate of the American Heart Association
  • University of Health Sciences Research Support Award (2002)
  • New Investigator Award - American Heart Association, Tennessee Affiliate
  • UHS Faculty Publication Award (2002)
  • 2nd Prize in the Nathan Burkan Memorial Competition (sponsored by the American Society of Composers, Authors and Publishers [ASCAP]) for paper entitled “Are Databases Adequately Protected by the 1976 Copyright Act in the Age of Bioinformatics?" (2003)
  • University of Missouri-Kansas City School of Law: Dean’s Honor List: Fall Semester 2004
  • Excellence Award in Molecular Medicine awarded at the Molecular Medicine: Applying Current and Emerging Technologies Conference, March 2008.


  • Biochemistry
  • Genetics
  • Pharmacology


BS, Juniata College ‐ Biology
PhD, Pennsylvania State University ‐ Genetics
JD, University of Missouri - Kansas City, School of Law

Contact Information

T: 678-225-7575


Scholarly Articles (26)