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About Denah Appelt

Dr. Appelt is a professor of Neuroscience in the department of Bio-Medical Sciences. She has served as the director for Basic and Clinical Neuroscience course in the DO curriculum and the director of the Neuroscience course in the Biomedical master program. Dr. Appelt lectures on neuroanatomy and participates in neuroanatomy labs in the DO SPOM course, Physician Assistant Studies, and Psychology program. In addition, Dr. Appelt is the director for the dual degree DO/PhD. program in Cellular and Molecular Biology designed to develop physician-scientist.

Positions

Present Professor Of Neuroscience, Dept. of Biomedical Sciences, Philadelphia College of Osteopathic Medicine Department of Bio-Medical Sciences
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Present Program Director, Dual DO/PhD. Biomedical Science Specialty Concentrations in the School of Health Sciences, Philadelphia College of Osteopathic Medicine Department of Bio-Medical Sciences
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Director, Biological Imaging Facility, Philadelphia College of Osteopathic Medicine
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Researcher, Center for Chronic Diseases of Aging, Philadelphia College of Osteopathic Medicine
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Grants

2003 - Present Chlamydia pneumoniae’s role in the pathogenesis of sporadic Alzheimer’s disease
Rose and Adolf Levis Foundation
Role: Co-PI
2013 - 2014 Bactericidal Implant Surfaces
CCDA
Role: Co-PI
2012 - 2013 Detection of Chlamydia pneumoniae in blood samples: A diagnostic screen for Alzheimer’s disease
CCDA
Role: Co-PI
2012 - 2013 Infection with Chlamydia Pneumoniae alters calcium-associated gene regulations and processes in neuronal cells and monocytes: Implications for Alzheimer’s disease
CCDA
Role: Co-PI
2009 - 2013 Dissecting the apoptosis pathway affected by C. pneumoniae in Alzheimer's disease
Health Research Formula Fund
Role: PI
2011 - 2012 Analysis by Real-Time PCR of Autophagy and Apoptosis in Neuronal Cells Infected with Chlamydia Pneumoniae
CCDA
Role: PI
2008 - 2009 Chlamydophila (Chlamydia) pneumoniae (Cpn) promotes Aβ 1-42 amyloid processing in Neuronal Cells: A Pathogenic Trigger for Alzheimer’s disease
CCDA
Role: PI
2007 - 2008 Effects on the apoptotic markers following a Chlamydial infection in neurons and astrocytes: Implications for Alzheimer’s disease
CCDA
Role: PI
2003 - 2008 Mechanisms of Cadmium Toxicity in Epithelial Cells
NIH - R01ES006478-09A2
Role: Collaborator
2004 - 2007 Chlamydia pneumoniae infection of Mice triggers Alzheimer-like pathology
Alzheimer Association
Role: Co-Investigator
1999 - 2004 Chlamydia pneumoniae: a pathogen in Alzheimer’s disease?
NIH/NIAID - R01 AI44055-01A1
Role: Co-Investigator
2001 - 2003 Immunosenescence and Chlamydia Pneumoniae
NIH/R15
Role: Co-Investigator
1999 - 2003 Investigation of Chlamydia pneumoniae in Diseases of the Aging
Foundation for Research into the Diseases of Aging
Role: Co-Investigator
1999 - 2000 Pathologic manifestations induced by Chlamydia Pneumonia infected glial cells in AD
National Foundation for Infectious Diseases
Role: PI
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Professional Service and Affiliations

2013 - Present Member, PCOM Presidential Diversity Council
2013 - Present Member, PCOM Research Committee
1999 - Present Member, PCOM D.O. Admissions Committee
2014 - 2015 Chair, PCOM Faculty Senate
2012 - 2014 Section Chair, Middle States Accreditation Self-Study Committee
2012 - 2013 Member, PCOM Faculty Search Committee
2010 - 2013 Member, PCOM Honors and Awards committee
2009 - 2013 Vice Chair, PCOM Institutional and Environmental Health and Safety Committee
2011 - 2012 Member, PCOM Chief Science Officer Search Committee
2009 - 2010 Member, PCOM Faculty Representative to Executive Faculty
2003 - 2009 Member, PCOM Appointment, Promotion and Tenure Committee
2007 - 2008 Secretary, PCOM Faculty Senate
2004 - 2004 Organizer, PCOM Symposium Challenging Views of Alzheimer’s Disease
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Honors and Awards

  • 2013 Lindback Distinguished Teaching Award
  • 2008 PCOM Teacher of the Year
  • 2003 Kappa SIgma Phi Award for Osteopathic Education
  • 1996 American Society for Cell Biology-Glenn Foundation Award for Outstanding Research in Aging

Education

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PhD, Drexel University College of Medicine
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BS, Juniata College
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Contact Information

p: 215-871-6164

Email:



Scholarly Articles (31)