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The identification of ganglion cells in Hirschsprung disease by the immunohistochemical detection of ret oncoprotein.
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  • Christopher Otis, MD, Baystate Health
  • David Gang, MD, Baystate Health
  • Sadiqa Karim, MD, Baystate Health
Document Type
Article, Peer-reviewed
Publication Date
The absence of ganglion cells (GCs) is the primary anatomic abnormality in Hirschsprung disease. Light microscopy is the mainstay in establishing this diagnosis. However, establishing a condition of aganglionosis may be challenging on routine H&E-stai
Citation Information
Am J Clin Pathol. 2006 Jul;126(1):1-6.