SelectedWorks - Christopher Otis MD

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Selected Works of Christopher Otis MD

Director, Division of Surgical Pathology

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About Christopher Otis MD

Present	Director, Division of Immunohistochemistry, Baystate Health
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Present	Director, Division of Surgical Pathology, Baystate Health
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Present	Professor of Pathology and Assistant Clinical Professor of Obstetrics and Gynecology, Tufts University School of Medicine
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Medicine and Health Sciences

Academic Achievement Award, Baystate Medical Center, 2005
Residency Teaching Award- Teacher of the Year, Department of Pathology, Baystate Medical Center, 2010
The Association of Directors of Anatomic and Surgical Pathology (past president)

Baystate Education and Research

Department of Pathology
759 Chestnut Street
Springfield, MA 01199

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Molecular assessment of testicular adult granulosa cell tumor demonstrates significant differences when compared to ovarian counterparts (Christopher Otis) All Scholarly Works (2021)

Testicular adult granulosa cell tumor (AGCT) is a rare type of sex-cord stromal tumor that affects patients of a wide age range and has the potential for late metastasis. In the testis, the diagnosis of ...

HER2 Protein Overexpression and Gene Amplification in Tubo-Ovarian High-grade Serous Carcinomas (Esma Ersoy, Qing Jackie Cao and Christopher Otis) All Scholarly Works (2021)

Most tubo-ovarian high-grade serous carcinomas (TO-HGSC) are diagnosed in advanced stages. Although the majority of patients achieve initial remission with cytoreductive surgery and chemotherapy, mortality rate remains high due to recurrent/progressive disease. The addition of ...

Mixed Endometrioid Adenocarcinoma and Müllerian Adenosarcoma of the Uterus and Ovary: Clinicopathologic Characterization With Emphasis on its Distinction From Carcinosarcoma (Christopher Otis) All Scholarly Works (2021)

Mullerian adenosarcoma is a biphasic neoplasm composed of benign or atypical Müllerian epithelium and a malignant mesenchymal component that is usually, but not always, of low grade. Focal architectural or cytologic atypia of the epithelial ...

Malignant Tumors of the Uterus and Ovaries With Mullerian and Germ Cell or Trophoblastic Components Have a Somatic Origin and Are Characterized by Genomic Instability (Christopher Otis) All Scholarly Works (2020)

Aims: Tumors of the female genital tract with a combination of malignant Mullerian and germ cell or trophoblastic tumor (MMGC/T) components are usually diagnosed in postmenopausal women and pursue an aggressive clinical course characterized by ...

The Current State of Communication of Urgent and Significant, Unexpected Diagnoses in Anatomic Pathology: Results of an Association of Directors of Anatomic and Surgical Pathology Survey (Christopher Otis) All Scholarly Works (2020)

CONTEXT.—: The concept of critical diagnoses in anatomic pathology is relatively recent and rigorous study of the issue is quite limited. The College of American Pathologists and Association of Directors of Anatomic and Surgical Pathology ...

Parasitic Microcalcifications of the Breast (Sanica Bhele and Christopher Otis) All Scholarly Works (2019)

Pathology Poster - 2019 (Anthony Cretara and Christopher Otis) Research and Education Posters (2019)

Pathology Poster - 2019

DNA methylation in breast cancers: Differences based on estrogen receptor status and recurrence (Rahul Jawale, Sallie Schneider and Christopher Otis) All Scholarly Works (2019)

DNA methylation plays a role in the etiology of primary breast cancers. We analyzed paired primary and second breast tumors to elucidate the role of methylation in recurrence. Methylation profiles from paired primary and second ...

CRTC1-MAML2 Fusion in Mucoepidermoid Carcinoma of the Breast (Christopher Otis) All Scholarly Works (2018)

AIMS: Mucoepidermoid carcinomas (MEC) are the most common malignant neoplasms of salivary glands but are uncommon in other sites. Salivary gland MEC are most frequently associated with CRTC1-MAML2 translocations. Exceedingly rare MEC of the breast ...

Perspectives and perceptions of urgent and alert values in surgical pathology and cytopathology: A survey of clinical practitioners and pathologists (Anthony Cretara and Christopher Otis) All Scholarly Works (2018)

In previous editorials, Chapman and Otis in 2011 and Layfield in 2014 have summarized much of the work responsible for establishing the concept of critical diagnoses in surgical pathology and cytopathology. Both editorials end with ...

DNA methylation in breast cancers: Differences based on estrogen receptor status and recurrence (Rahul Jawale, Sallie Schneider and Christopher Otis) All Scholarly Works (2018)

DNA methylation plays a role in the etiology of primary breast cancers. We analyzed paired primary and second breast tumors to elucidate the role of methylation in recurrence. Methylation profiles from paired primary and second ...

TROP2 methylation and expression in tamoxifen-resistant breast cancer (Rahul Jawale, Christopher Otis and Sallie Schneider) All Scholarly Works (2018)

Background: The DNA methyltransferase 1 inhibitor, 5-Aza-2'-deoxycytidine (5-Aza-dC) is a potential treatment for breast cancer. However, not all breast tumors will respond similarly to treatment with 5-Aza-dC, and little is known regarding the response of ...

Data Set for the Reporting of Carcinomas of the Cervix: Recommendations From the International Collaboration on Cancer Reporting (ICCR (Christopher Otis) All Scholarly Works (2018)

A comprehensive pathologic report is essential for optimal patient management, cancer staging and prognostication. In many countries, proforma reports are used but the content of these is variable. The International Collaboration on Cancer Reporting is ...

Template for Reporting Results of Biomarker Testing of Specimens From Patients With Carcinoma of the Endometrium (Christopher Otis) All Scholarly Works (2017)

Intravenous leiomyomatosis: an unusual intermediate between benign and malignant uterine smooth muscle tumors (Monica Hollowell and Christopher Otis) All Scholarly Works (2016)

Intravenous leiomyomatosis is an unusual smooth muscle neoplasm with quasi-malignant intravascular growth but a histologically banal appearance. Herein, we report expression and molecular cytogenetic analyses of a series of 12 intravenous leiomyomatosis cases to better ...

ELF5 and DOK7 regulation in anti-estrogen treated cells and tumors (Rahul Jawale and Christopher Otis) All Scholarly Works (2016)

BACKGROUND: Most women with primary breast cancers that express estrogen receptor alpha (ER or ESR1) are treated with endocrine therapies including the anti-estrogen tamoxifen, but resistance to these anti-endocrine therapies often develops. This study characterizes ...

Interpretive Diagnostic Error Reduction in Surgical Pathology and Cytology: Guideline From the College of American Pathologists Pathology and Laboratory Quality Center and the Association of Directors of Anatomic and Surgical Pathology (Christopher Otis) All Scholarly Works (2016)

Context .- Additional reviews of diagnostic surgical and cytology cases have been shown to detect diagnostic discrepancies. Objective .- To develop, through a systematic review of the literature, recommendations for the review of pathology cases ...

Validating whole slide imaging for diagnostic purposes in pathology: guideline from the College of American Pathologists Pathology and Laboratory Quality Center (Christopher Otis) All Scholarly Works (2013)

CONTEXT: There is increasing interest in using whole slide imaging (WSI) for diagnostic purposes (primary and/or consultation). An important consideration is whether WSI can safely replace conventional light microscopy as the method by which pathologists ...

Paralemmin-1 is over-expressed in estrogen-receptor positive breast cancers (Sallie Smith-Schneider, Sharon Marconi, Christopher Otis, et al.) All Scholarly Works (2012)

BACKGROUND: Paralemmin-1 is a phosphoprotein lipid-anchored to the cytoplasmic face of membranes where it functions in membrane dynamics, maintenance of cell shape, and process formation. Expression of paralemmin-1 and its major splice variant (Δ exon ...

Diagnostic accuracy of image-guided percutaneous fine needle aspiration biopsy of the mediastinum (Margaret Assaad, Christopher Otis and Liron Pantanowitz) All Scholarly Works (2007)