SelectedWorks - Brian B. Gowen

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Selected Works of Brian B. Gowen

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About Brian B. Gowen

Present	Research Assistant Professor, Utah State University ‐ Animal, Dairy and Veterinary Sciences
Institution Organization Position Type Position Title Time Period to Options Current Position Affiliate my profile with this Institution

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Animal Sciences

Antiviral research

1993 - Delano F.Scott Scholarship
1994 - Phi Beta Kappa, Delta Chapter of Colorado
1994 - National Collegiate Medical Professions Award
1994 - All-American Scholar Collegiate Award
2000 - Intramural Research Training Award, National Institute of Allergy and Infectious Diseases
2007-2008 - President, American Society for Microbiology, Intermountain Branch
2009-2011 - Councilor, American Society for Mictrobiology, Intermountain Branch

Mail address:
Utah State University
5600 Old Main Hill
Logan, UT 84322-5600
Location:
Veterinary Science Building, Room 207
Office Phone:
(435) 797-3112
Fax:
(435) 797-3959

Email:

Articles (43)

Characterization of a Novel STAT 2 Knock Out Hamster Model ...

Scientific Reports (2020)

Charlene Ranadheera, Emelissa J. Valcourt, Bryce M. Warner, Guillaume Poliquin, et al.

Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne pathogen causing a febrile illness in humans, which can progress to hemorrhagic ...

Type I Interferon Underlies Severe Disease Associated with Junín Virus ...

Brady T. Hickerson, Eric J. Sefing, Kevin W. Bailey, Arnaud J Van Wettere, et al.

Junín virus (JUNV) is one of five New World mammarenaviruses (NWMs) that causes fatal hemorrhagic disease in humans and is ...

Theoretical Risk of Genetic Reassortment Should Not Impede Development of ...

Vaccine: X (2020)

Thomas P. Monath, Jeroen Kortekaas, Douglas M. Watts, Rebecca C. Christofferson, et al.

In November 2019, The World Health Organization (WHO) issued a draft set of Target Product Profiles (TPPs) describing optimal and ...

Guinea Pig Transferrin Receptor 1 Mediates Cellular Entry of Junín ...

Journal of Virology (2020)

Brady T. Hickerson, Jonna B. Westover, Zhongde Wang, Young-Min Lee, et al.

Several clade B New World arenaviruses (NWAs) can cause severe and often fatal hemorrhagic fever, for which preventive and therapeutic ...

Vascular Leak and Hypercytokinemia Associated with Severe Fever with Thrombocytopenia ...

Pathogens (2019)

Jonna B. Westover, Brady T. Hickerson, Arnaud J. Van Wettere, Brett L. Hurst, et al.

Severe fever with thrombocytopenia syndrome (SFTS) is an emerging viral hemorrhagic fever (VHF) endemic to China, South Korea, Japan, and ...

A Potent Lassa Virus Antiviral Targets an Arenavirus Virulence Determinant

Pathogens (2018)

Ikenna G. Madu, Megan Files, Dima N. Gharaibeh, Amy L. Moore, et al.

Arenaviruses are a significant cause of hemorrhagic fever, an often-fatal disease for which there is no approved antiviral therapy. Lassa ...

Use of Favipiravir to Treat Lassa Virus Infection in Macaques

Emerging Infectious Diseases (2018)

Kyle Rosenke, Heinz Feldmann, Jonna B. Westover, Patrick William Hanley, et al.

Lassa virus, the cause of Lassa fever in humans, is endemic to West Africa. Treatment of Lassa fever is primarily ...

T-705 (Favipiravir) Inhibition of Arenavirus Replication in Cell Culture

Antimicrobial Agents and Chemotherapy (2011)

Michelle Mendenhall, Andrew Russell, Terry Juelich, Emily L. Messina, et al.

A number of New World arenaviruses (Junin [JUNV], Machupo [MACV], and Guanarito [GTOV] viruses) can cause human disease ranging from ...

Effective Oral Favipiravir (T-705) Therapy Initiated after the Onset of ...

PLoS Neglected Tropical Diseases (2011)

M. Mendenhall, A. Russell, Donald F. Smee, Jeffery O. Hall, et al.

Background Lassa and Junín viruses are the most prominent members of the Arenaviridae family of viruses that cause viral hemorrhagic ...

Maporal virus as asurrogate for pathogenic New World hantaviruses and ...

Antiviral Chemistry & Chemotherapy (2011)

K. K. Buys, K. H. Jung, Donald F. Smee, Y. Furuta, et al.

Background: Pathogenic hantaviruses geographically distributed in the Old World cause haemorrhagic fever with renal syndrome (HFRS), whereas New World hantaviruses ...

Progress in the experimental therapy of severe arenaviralinfections

Future Microbiology (2011)

Brian B. Gowen and M. Bray

A number of viruses in the family Arenaviridae cause severe illness in humans. Lassa virus in West Africa and a ...

T-705(Favipiravir) inhibition of arenavirus replication in cell culture

Antimicrobial Agents and Chemotherapy (2011)

M. Mendenhall, A. Russell, T. Juelich, E. L. Messina, et al.

A number of New World arenaviruses (Junín [JUNV], Machupo [MACV], and Guanarito [GTOV] viruses) can cause human disease ranging from ...

Use ofrecombinant adenovirus vectored 1 consensus IFN-α to avert severe ...

PLoS ONE (2011)

Brian B. Gowen, J. Ennis, A. Russell, E. J. Sefing, et al.

Several arenaviruses can cause viral hemorrhagic fever, a severe disease with case-fatality rates in hospitalized individuals ranging from 15-30%. Because ...

Assessing changes in vascular permeability in a hamster model ofviral ...

Virology Journal (2010)

Brian B. Gowen, Justin G. Julander, N. R. London, M. H. Wong, et al.

Background A number of RNA viruses cause viral hemorrhagic fever (VHF), in which proinflammatory mediators released from infected cells induce ...

Development of a new Tacaribearenavirus infection model and its use ...

PLoS ONE (2010)

Brian B. Gowen, M. H. Wong, D. Larson, W. Ye, et al.

Background A growing number of arenaviruses can cause a devastating viral hemorrhagic fever (VHF) syndrome. They pose a public health ...

Efficacy of Favipiravir (T-705) and T-1106 Pyrazine Derivatives in Phlebovirus ...

Antiviral Research (2010)

Brian B. Gowen, M. H. Wong, K. H. Jung, Donald F. Smee, et al.

Several studies have reported favipiravir (T-705) to be effective in treating a number of viral diseases modeled in rodent systems. ...

A Biotechnological Product and Its Potential as a New Immunomodulator ...

Antiviral Research (2009)

N. Duran, Brian B. Gowen, F. T. Costa, G. Z. Justo, et al.

Intracellular pathogens with widespread drug-resistance contribute substantially to the increasing rates in morbidity and mortality due to emerging and reemerging ...

Prophylaxis with cationic liposome-DNA complexes protects hamstersfrom phleboviral disease: importance ...

Antiviral Research (2009)

Brian B. Gowen, J. Fairman, S. W. Dow, R. Troyer, et al.

Cationic liposome–DNA complexes (CLDC) are cationic/neutral lipid carriers complexed with plasmid DNA that when administered systemically results in a robust ...

PuntaToro virus (Bunyaviridae, Phlebovirus) infection in mice: strain differences inpathogenesis ...

Virology (2009)

M. Mendenhall, M. H. Wong, Ramona T. Skirpstunas, John D Morrey, et al.

The Adames strain of Punta Toro virus (PTV-A, Bunyaviridae, Phlebovirus) causes an acute lethal disease in hamsters and mice. The ...

T-705 (favipiravir) and related compounds: Novelbroad-spectrum inhibitors of RNA viral ...

T-705 (favipiravir) and related compounds: Novelbroad-spectrum inhibitors of RNA viral infections (2009)

Y. Furuta, K. Takahashi, K. Shiraki, K. Sakamoto, et al.

A series of pyrazinecarboxamide derivatives T-705 (favipiravir), T-1105 and T-1106 were discovered to be candidate antiviral drugs. These compounds have ...

Animal models of highly pathogenic RNA viralinfections: Encephalitis viruses

Antiviral Research (2008)

M. R. Holbrook and Brian B. Gowen

The highly pathogenic RNA viruses that cause encephalitis include a significant number of emerging or re-emerging viruses that are also ...

Animal models of highly pathogenic RNA viralinfections: Hemorrhagic fever viruses

Antiviral Research (2008)

Brian B. Gowen and M. R. Holbrook

A diverse group of highly pathogenic RNA viruses cause a severe multisystemic illness in humans commonly referred to as viral ...

Immunoprophylaxis of Punta Toro virus (Phlebovirus,Bunyaviridae) infection in hamsters ...

International Immunopharmacology (2008)

Brian B. Gowen, J. W. Judge, M. H. Wong, K. H. Jung, et al.

Recombinant Eimeria antigen (rEA) has been shown to have potent anticancer and antiviral activity in respective mousedisease models, presumably through ...

Potent in vitro activity of the albumin fusion type 1interferons ...

Chemotherapy (2008)

G. M. Subramanian, P. A. Moore, Brian B. Gowen, Aaron L. Olsen, et al.

Background: The type 1 interferons (INF-α and INF-β) are potent antiviral agents. Albumin-INF-α and albumin-INF-β are novel recombinant proteins consisting ...

Prophylactic and Therapeutic Intervention of Punta Toro Virus (Phlebovirus, Bunyaviridae ...

Antiviral Research (2008)

Brian B. Gowen, M. H. Wong, K. H. Jung, L. M. Blatt, et al.

Punta Toro virus (PTV) is a member of the Bunyaviridae family, genus Phlebovirus, related to the highly pathogenic Rift Valley ...