|Present||Roberta and G. Robert Couch Assistant Professor, Missouri University of Science and Technology ‐ Materials Science and Engineering|
|2006 - 2018||Research Associate Professor in Bioengineering, University of Washington|
Professional Service and Affiliations
|2022 - Present||Senior Member (elected), National Academy of Inventors (NAI)|
|2011||PhD in Polymer Science and Engineering, University of Southern Mississippi|
|2006||B.S. in Polymer Science, University of Southern Mississippi|
223 McNutt Hall
Missouri University of Science and Technology
Rolla, MO 65409
Research Works (60)
Liver Targeted Primaquine Drugamers for the Treatment of Malaria in ...
Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium (2019)
Statement of purpose: Malaria still exists as a serious global health issues despite extensive measures to eradicate the disease and ...
Fully Synthetic Macromolecular Prodrug Chemotherapeutics with EGFR Targeting and Controlled ...
Polymer Chemistry (2018)
Herein, we developed a fully polymerizable, peptide-targeted, camptothecin polymeric prodrug system. Two prodrug monomers were synthesized via esterification of camptothecin ...
Macrophage-Targeted Drugamers with Enzyme-Cleavable Linkers Deliver High Intracellular Drug Dosing ...
Journal of Controlled Release (2018)
Intracellular bacterial infections localized to the lung alveolar macrophage (AM) remain one of the most challenging settings for antimicrobial therapy. ...
Polymer-Augmented Liposomes Enhancing Antibiotic Delivery Against Intracellular Infections
Biomaterials Science (2018)
Pulmonary intracellular infections, such as tuberculosis, anthrax, and tularemia, have remained a significant challenge to conventional antibiotic therapy. Ineffective antibiotic ...
Synthetic Macromolecular Antibiotic Platform for Inhalable Therapy Against Aerosolized Intracellular ...
Molecular Pharmaceutics (2017)
Lung-based intracellular bacterial infections remain one of the most challenging infectious disease settings. For example, the current standard for treating ...
Nanostructured Glycopolymer Augmented Liposomes to Elucidate Carbohydrate-Mediated Targeting
Nanomedicine: Nanotechnology, Biology and Medicine (2016)
Carbohydrate receptors on alveolar macrophages are attractive targets for receptor-mediated delivery of nanostructured therapeutics. In this study, we employed reversible ...
Synthesis of Zwitterionic, Hydrophobic, and Amphiphilic Polymers: Via RAFT Polymerization ...
Polymer Chemistry (2016)
Polymerization induced self-assembly (PISA) in acetic acid was employed to polymerize the hydrophilic sulfobetaine monomer 2-(N-3-sulfopropyl-N,N-dimethyl ammonium)ethyl methacrylate (DMAPS) and ...
Chemotherapeutic Copolymers Prepared: Via the RAFT Polymerization of Prodrug Monomers
Polymer Chemistry (2016)
Reversible addition-fragmentation chain transfer (RAFT) polymerization was employed to prepare prodrug polymer carrier systems with the chemotherapeutic agent camptothecin (Cam) ...
Antibody Targeting Facilitates Effective Intratumoral SiRNA Nanoparticle Delivery to HER2-Overexpressing ...
The therapeutic potential of RNA interference (RNAi) has been limited by inefficient delivery of short interfering RNA (siRNA). Tumor-specific recognition ...