|Present||Professor, University of Texas at Tyler ‐ Biology|
Honors and Awards
- President, North Texas Chapter of Associates of Clinical Research Professionals (ACRP) - 2007-2008
- President, American Society for Microbiology - July 2015
- National Academies Education Fellow in the Life Sciences- 2013
- Associate Editor, Drug Design & Delivery (Open Access, UK) - 2014
- President, American Society for Microbiology - July 2015
- BIOL 1106: General Biology Lab I & II
- BIOL 2201: Anatomy and Physiology Lab I & II
- BIOL 2301: Anatomy and Physiology I & II
- BIOL 4199: Independent Study - Bacterial Pathogenesis
- BIOL 4350: Immunology
- BIOL 5193: Graduate Seminar
- BIOL 5199: Independent Study - Cell Signaling
- BIOL 5380: Cellular Physiology
- BIOL 5383: Host-Pathogen Interaction
- BIOL 5396: Thesis, Cellular and Molecular Mechanisms of Bacterial Pathogenesis and Therapeutics
|1986||Ph.D., Texas Woman's University ‐ Radiation Microbiology|
|1981||M.S., Texas Woman's University ‐ Microbiology|
|1972||B.S., University of Tabriz, Tabriz, Iran ‐ Medical Technology|
Research Works (44)
Time course of resolution of adhesions during fibrinolytic therapy in tetracycline-induced pleural injury in rabbits American Journal of Physiology - Lung Cellular and Molecular Physiology (2015)
The time required for the effective clearance of pleural adhesions/organization after intrapleural fibrinolytic therapy (IPFT) is unknown. Chest ultrasonography and computed tomography (CT) were used to assess the efficacy of IPFT in a rabbit model ...
Mechanism of Fibroblasts Inflammatory Response to Pseudomonas aeruginosa Elastase Microbiology (2014)
Receptor tyrosine kinases, including the epidermal growth factor receptors (EGFR), are able to activate the mitogen-activated protein kinases (MAPK) via several adaptor proteins and protein kinases such as Raf. EGFR can be activated by a ...
Active α-macroglobulin is a reservoir for urokinase after fibrinolytic therapy in rabbits with tetracycline-induced pleural injury and in human pleural fluids American Journal of Physiology - Lung Cellular and Molecular Physiology (2013)
Intrapleural processing of prourokinase (scuPA) in tetracycline (TCN)-induced pleural injury in rabbits was evaluated to better understand the mechanisms governing successful scuPA-based intrapleural fibrinolytic therapy (IPFT), capable of clearing pleural adhesions in this model. Pleural ...
Intrapleural adenoviral delivery of human plasminogen activator inhibitor-1 exacerbates tetracycline-induced pleural injury in rabbits. American Journal of Respiratory Cell and Molecular Biology (2013)
Elevated concentrations of plasminogen activator inhibitor–1 (PAI-1) are associated with pleural injury, but its effects on pleural organization remain unclear. A method of adenovirus-mediated delivery of genes of interest (expressed under a cytomegalovirus promoter) to ...
Liposomal antibiotics for the treatment of infectious diseases Expert Opinion on Drug Delivery (2013)
Introduction: Liposomal delivery systems have been utilized in developing effective therapeutics against cancer and targeting microorganisms in and out of host cells and within biofilm community. The most attractive feature of liposome-based drugs are enhancing ...
Inhibition of PKC attenuates Pseudomonas aeruginosa elastase-induced epithelial barrier disruption American Journal of Respiratory Cell and Molecular Biology (2011)
Pseudomonas aeruginosa pulmonary infection compromises the human airway epithelium, and can be especially devastating to immunocompromised or debilitated individuals. We have reported earlier that P. aeruginosa elastase (PE) increases paracellular permeability in epithelial cell monolayers ...
Intrapleural low-molecular-weight urokinase or tissue plasminogen activator versus single-chain urokinase in tetracycline-induced pleural loculation in rabbits Experimental Lung Research (2009)
The authors compared the ability of a single dose of the proenzyme single-chain urokinase (scuPA), low-molecular-weight urokinase, tissue plasminogen activator (tPA), or a mutant site-inactive scuPA to resolve intrapleural loculations at 72 to 96 hours ...
Regulation of the Inflammatory Response in Health and Disease (2009)
The ability of multi-cellular organisms to mount a concerted response is an evolutionary advantage. In the case of bacterial challenges, the multicellular organism is tested by a diverse, complex and dynamic challenges, and must adapt ...
Activity and Interactions of Liposomal Antibiotics in Presence of Polyanions and Sputum of Patients with Cystic Fibrosis Biology Faculty Publications and Presentations (2009)
Background: To compare the effectiveness of liposomal tobramycin or polymyxin B against Pseudomonas aeruginosa in the Cystic Fibrosis (CF) sputum and its inhibition by common polyanionic components such as DNA, F-actin, lipopolysaccharides (LPS), and lipoteichoic ...
Bismuth–thiol incorporation enhances biological activities of liposomal tobramycin against bacterial biofilm and quorum sensing molecules production by Pseudomonas aeruginosa International Journal of Pharmaceutics (2009)
Recurrent pulmonary infection and inflammation are major risk factors for high morbidity and mortality in patients with cystic fibrosis (CF). As such, frequent antibiotic use and drug resistant bacterial strains are main concerns in individuals ...
Co-encapsulation of gallium with gentamicin in liposomes enhances antimicrobial activity of gentamicin against Pseudomonas aeruginosa Journal of Antimicrobial Chemotherapy (2008)
The aim of this study was to enhance the antimicrobial efficacy of a liposomal gentamicin formulation with gallium metal (Lipo-Ga-GEN) against clinical isolates of Pseudomonas aeruginosa. Sputum isolates of P. aeruginosa from cystic fibrosis patients were ...
Pseudomonas aeruginosa elastase induces IL-8 production in the lung cells via the epidermal growth factor/extracellular signal-regulated proteins/NFÎºB pathway Biology Faculty Publications and Presentations (2008)
Background: The induction of chemokine secretion by fibroblasts is crucial for the migration of leukocytes into the parenchyma of the injured lung. Several bacterial products activate the lung’s structural as well as immune cells to ...
Liposomal Bismuth-Ethanedithiol Formulation Enhances Antimicrobial Activity of Tobramycin International Journal of Pharmaceutis (2008)
Pseudomonas aeruginosa and Burkholderia cenocepacia (formally, genomovar III genotype of Burkholderia cepacia complex) have emerged as serious opportunistic resistant pathogens in patients with cystic fibrosis (CF). We have developed a liposomal formulation containing bismuth-ethanedithiol (BiEDT) and tobramycin to overcome bacterial ...
Bactericidal efficacy of liposomal aminoglycosides against Burkholderia cenocepacia Journal of Antimicrobial Chemotherapy (2007)
Objectives Burkholderia cenocepacia (formally a genotype of Burkholderia cepacia complex called genomovar III) has emerged as a serious opportunistic pathogen in individuals with cystic fibrosis. We developed a liposomal antibiotic formulation composed of 1,2-distearoyl-sn-glycero-3-phosphocholine and ...
Antioxidants preserve macrophage phagocytosis of Pseudomonas aeruginosa during hyperoxia Free Radical Biology and Medicine (2007)
Pseudomonas. aeruginosa (PA) is a leading cause of nosocomial pneumonia in patients receiving mechanical ventilation with hyperoxia. Exposure to supraphysiological concentrations of reactive oxygen species during hyperoxia may result in macrophage damage that reduces their ...
Artificial Neural Network-Based Estimation for Pseudomonas aeruginosa Experiments IEEE Proceedings (2007)
Pseudomonas aeruginosa (PE), a ubiquitous bacterium, has an overwhelming presence among hospitals and nursing homes. Common infections and inflammation caused by PE are acute pneumonia and infection related pulmonary complications in cystic fibrosis patients. We ...
Intrapleural activation, processing, efficacy, and duration of protection of single-chain urokinase in evolving tetracycline-induced pleural injury in rabbits American Journal of Physiology - Lung Cellular and Molecular Physiology (2007)
Intrapleural fibrinolysins have been used to treat pleural loculations. However, the efficacy of clinically available agents has recently been questioned, providing a rationale for investigation of new interventions. Single-chain urokinase plasminogen activator resists inhibition by ...
Mechanism of Enhanced Activity of Liposome-Entrapped Aminoglycosides against Resistant Strains of Pseudomonas aeruginosa Biology Faculty Publications and Presentations (2006)
Pseudomonas aeruginosa is inherently resistant to most conventional antibiotics. The mechanism of resistance of this bacterium is mainly associated with the low permeability of its outer membrane to these agents. We sought to assess the ...
Antibacterial activity of liposomal gentamicin against Pseudomonas aeruginosa: a time–kill study International Journal of Antimicrobial Agents (2006)
Cystic fibrosis (CF) is a common and lethal genetic disorder with a carrier frequency of 1 in 29 Caucasians. Chronic respiratory infections with Pseudomonas aeruginosa are the leading cause of morbidity and mortality in individuals ...
Preparation and characterization of dehydration–rehydration vesicles loaded with aminoglycoside and macrolide antibiotics International Journal of Pharmaceutics (2006)
Enhanced activity of liposomes-encapsulated antibiotics against clinical isolates of Pseudomonas aeruginosa has been documented with liposomes of low encapsulation efficiency. We sough to construct liposomes with high yield entrapment of aminoglycoside and macrolide antibiotics as ...
Liposome-mediated gentamicin delivery: development and activity against resistant strains of Pseudomonas aeruginosa isolated from cystic fibrosis patients The Journal of Antimicrobial Chemotherapy (2005)
Objectives: Chronic pulmonary infection by Pseudomonas aeruginosa in cystic fibrosis patients is virtually impossible to eradicate by means of existing free antibiotics. We sought to assess the antibacterial activities of liposomal gentamicin against clinical isolates ...
Antimicrobial efficacy of a new antibiotic-loaded poly(hydroxybutyric-co-hydroxyvaleric acid) controlled release system Journal of Antimicrobial Chemotherapy (2004)
Objective: Failure of orthopaedic devices, mainly femoral hip replacements, due to infection is of increasing medical importance. There is a need for improved antibiotic delivery systems in the treatment of orthopaedic infections and here we ...