Presentation
Space Radiation Effects and Countermeasures Using a Novel Human Neural Model and Organic Nanoparticles
44th COSPAR Scientific Assembly
(2022)
Abstract
Space radiation (Proton and High Charge Energy particles (HZE) from solar particle events and galactic cosmic rays (GCR)) pose health risks during deep-space human exploration missions. Secondary radiation particles emitted by the spaceship shielding and the planetary soil are also must be concerned. Based on animal models, space radiobiological investigations indicates that HZE and protons altered central nerve behavior, resulting in behavior changes, aging, neurodegenerative disease, and neurogenesis problems caused by chronic DNA damage, oxidative stress, and inflammation. A challenge is to predict the risk of space exposure affecting individual human performance using human-based models. We built a cultured human neuron system produced from human induced pluripotent stem cells (HiPSC) with the goal of identifying radioresistant factors and creating radioprotective agents for space health. We found that DNA repair modulators, energy depletion, and thermodynamic perturbations all contribute to the regulation of radiation effect in human neuron models using a genetically transduced calcium indicator (GcAMP6f). We also found a unique radiation protection material based on copper oxide and zinc oxide nanoparticles from vegetable extracts. This study will present a biological and physical strategy for space radiation counter measures.
Disciplines
Publication Date
Summer July 16, 2022
Citation Information
Addisie Geremew. "Space Radiation Effects and Countermeasures Using a Novel Human Neural Model and Organic Nanoparticles" 44th COSPAR Scientific Assembly (2022) Available at: http://works.bepress.com/addisie-geremew/10/