High Dimensional Data
Comparative evaluation of classifiers in the presence of statistical interaction between features in high-dimensionality data settings (with Yu Guo), International Journal of Biostatistics (2012)
Background: A central challenge in high dimensional data settings in biomedical investigations involves the estimation...
Sample size and statistical power considerations in high-dimensionality data settings: a comparative study of classification algorithms (with Yu Guo, Armin Garber, and Robert N. McBurney), BMC Bioinformatics (2010)
Background: Data generated using ‘omics’ technologies are characterized by high dimensionality, where the number of...
The impact of storage effects in biobanks on biomarker discovery in systems biology studies (with L Mueller, K Kugler, W Hackl, L Pleyer, M Dehmer, and A Graber), Biomarkers (2010)
Sample handling and storage conditions in specimens frozen over long periods of time can severely...
Assessing network structure in the presence of measurement error (with Denise Scholtens and Robert Gentleman), Statistical Advances in the Biomedical Sciences (2007)
A graph-theoretic approach to testing associations between disparate sources of functional genomics data (with Thomas LaFramboise, Denise Scholtens, and Robert Gentleman), Bioinformatics (2004)
Motivation: The last few years have seen the advent of high-throughput technologies to analyze various...
General Biostatistics
Estimating HIV Incidence Based on Combined Prevalence Testing (with Stephen W. Lagakos), Biometrics (2010)
Knowledge of incidence rates of HIV and other infectious diseases is important in evaluating the...
Analyzing Time-to-Event Data in a Clinical Trial When an Unknown Proportion of Subjects Has Experienced the Event at Entry (with Stephen W. Lagakos), Biometrics (2004)
In some clinical trials, where the outcome is the time until development of a silent...
Estimation of a failure time distribution based on imperfect diagnostic tests (with Stephen W. Lagakos), Biometrika (2003)
Sequentially-administered diagnostic tests used to determine the occurrence of a silent event are sometimes subject...
Estimation of timing of mother-infant transmission of HIV (with Stephen W. Lagakos), Biometrics (2001)
Knowledge of the timing of perinatal transmission of HIV would be valuable for the determination...
HIV
Maternal Toxicity and Pregnancy Outcome According to Antiretroviral Therapy during Pregnancy: An analysis of the PACTG 316 Study (with H D. Watts, R Maupin, I Delke, C Cunningham, A Dorenbaum, S Fiore, M L. Newell, J F. Delfraissy, R D. Gelber, L Mofenson, M Culnane, and J L. Sullivan), American Journal of Obstetrics and Gynecology (2004)
BACKGROUND: Antiretroviral therapy (ART) during pregnancy reduces the risk of perinatal transmission of HIV-1 but...
The Impact of Race/Ethnicity on Mother-to-Child HIV Transmission in the U.S. in Pediatric AIDS Clinical Trials Group Protocol 316 (with C K. Cunningham, I Delke, R Maupin, L Mofenson, A Dorenbaum, J L. Sullivan, A Gonzalez-Garcia, E Thorpe, M Rathore, and R D. Gelber), Journal of the Acquired Immune Deficiency Syndrome (JAIDS) (2004)
The present analysis was designed to determine whether race/ethnicity was independently associated with mother-to-child HIV-1...
Mathematics
Ruling out (160,54,18) difference sets in some nonabelian groups (with Jason Alexander, Jeremy Martin, Kimberly Monahan, and Harriet Pollatsek), Journal of Combinatorial Designs (2000)
We prove the following theorems. Theorem A. Let G be a group of order 160...
Systems Biology
Detection of promoter methylation of tumor suppressor genes in serum DNA of breast cancer cases and benign breast disease controls (with Susan R. Sturgeon, Catherine Schairer, Hyman B. Muss, Regina G. Ziegler, and Kathleen F. Arcaro), Epigenetics (2012)
Tumors are capable of shedding DNA into the blood stream. This shed DNA may be...
The Liver Toxicity Biomarker Study Phase 1: Markers for the Effects of Tolcapone or Entacapone (with Robert N. McBurney, Wade M. Hines, L S. Vontungeln, L K. Schnackenberg, R D. Beger, C L. Moland, T Han, J C. Fuscoe, C W. Chang, J J. Chen, Z Su, X H. Fan, W Tong, S A. Booth, P L. Courchesne, J M. Campbell, A Graber, Y Guo, P Juhasz, T Y. Li, M D. Lynch, N M. Morel, T N. Plasterer, E J. Takach, C Zeng, and F A. Beland), Toxicologic Pathology (2012)
The Liver Toxicity Biomarker Study is a systems toxicology approach to discover biomarkers that are...
A systems biology approach to understanding elevated serum alanine transaminase levels in a clinical trial with ximelagatran (with U Andersson, J Lindberg, S Wang, M Marcusson-Sthl, M Hannula, C Zeng, P J. Juhasz, J Kolmert, J Bckstrm, L Nord, K Nilsson, S Martin, B Glinghammer, K Cederbrant, and I Schuppe-Koistinen), Biomarkers (2009)
Ximelagatran was developed for the prevention and treatment of thromboembolic conditions. However, in long-term clinical...
Systems Pharmacology, Biomarkers and Biomolecular Networks (with Aram Adourian, T N. Plasterer, Ezra Jennings, Shunguang Wang, Jan van der Greef, Robert N. McBurney, Pieter Muntendam, and Noubar Afeyan), Drug Efficacy, Safety, and Biologics Discovery: Emerging Technologies and Tools (2009)
The Liver Toxicity Biomarker Study: Phase I Design and Preliminary Results (with Robert N. McBurney, Wade M. Hines, L S. Von Tungeln, L K. Schnackenberg, R D. Beger, C L. Moland, T Han, J C. Fuscoe, C Chang, J J. Chen, Z Su, X Fan, W Tong, S A. Booth, P L. Courchesne, J M. Campbell, A Graber, Yu Guo, T Y. Li, Moira Lynch, Nicole M. Morel, T Plasterer, E J. Takach, C Zeng, and F A. Beland), Toxicologic Pathology (2009)
Drug-induced liver injury (DILI) is the primary adverse event that results in withdrawal of drugs...
Women's Health Initiative
Common genetic variants in Peroxisome Proliferator-activated Receptor γ (PPARG) and Clinical Diabetes Risk among Women’s Health Initiative Postmenopausal Women (with K HK Chan, T Niu, Y Ma, N Y. You, Y Song, E Sobel, Y Hsu, Y Qiao, L Tinker, and S Liu), Journal of Clinical Endocrinology & Metabolism (2013)
Determinants of Racial/Ethnic Disparities in Incidence of Clinical Diabetes in Postmenopausal Women in the United States: The Women’s Health Initiative 1993-2009 (with Yunsheng Ma, James R. Hebert, JoAnn E. Manson, Simin Liu, M Lamonte, Chloe E. Bird, Judith K. Ockene, Yongxia Qiao, Barbara Olendzki, K L. Schneider, M C. Rosal, Deidre M. Sepavich, J Wactawski-Wende, M Stefanick, L S. Phillips, Ira S. Ockene, R C. Kaplan, G E. Sarto, L Garcia, and Barbara V. Howard), Diabetes Care (2012)
OBJECTIVE To examine determinants of racial/ethnic differences in diabetes incidence among postmenopausal women participating in...
Sleep duration and endometrial cancer risk (with Susan R. Sturgeon, Nicole Luisi, and Katherine W. Reeves), Cancer Causes and Control (2012)
PURPOSE: Recent data indicate that night shift work is associated with increased endometrial cancer risk,...
Statin Use and Risk of Diabetes in Postmenopausal Women in the Women’s Health Initiative (with Annie L. Culver, Ira S. Ockene, Barbara C. Olendzki, Deidre M. Sepavich, J Wactawski-Wende, JoAnn E. Manson, Yongxia Qiao, Simin Liu, P A. Merriam, C Rahilly-Tierny, F Thomas, J S. Berger, Judith K. Ockene, D J. Curb, and Yunsheng Ma), Archives of Internal Medicine (2012)
BACKGROUND: This study investigates whether the incidence of new-onset diabetes mellitus (DM) is associated with...
Caffeinated coffee, decaffeinated coffee and endometrial cancer risk: A prospective cohort study among U.S. postmenopausal women (with Ayush Giri, Susan R. Sturgeon, Nicole Luisi, Elizabeth Bertone-Johnson, and Katherine W. Reeves), Nutrients (2011)
There is plausible biological evidence as well as epidemiologic evidence to suggest coffee consumption may...
Epigenetics
Detection of promoter methylation of tumor suppressor genes in serum DNA of breast cancer cases and benign breast disease controls (with Susan R. Sturgeon, Catherine Schairer, Hyman B. Muss, Regina G. Ziegler, and Kathleen F. Arcaro), Epigenetics (2012)
Tumors are capable of shedding DNA into the blood stream. This shed DNA may be...