SelectedWorks - Lila Gierasch

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Selected Works of Lila Gierasch

Distinguished Professor, Department of Biochemsitry and Molecular Biology, College of Natural Sciences

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About Lila Gierasch

Present	Distinguished Professor, Department of Biochemsitry and Molecular Biology, College of Natural Sciences, University of Massachusetts Amherst
Institution Organization Position Type Position Title Time Period to Options Current Position Affiliate my profile with this Institution

Biochemistry and Molecular Biology

Protein Folding in the Cell

2014 Mildred Cohn Award from the American Society of Biochemistry and Molecular Biology
2014 Biophysical Society Fellowship
A.P. Sloan Fellowship
Vincent du Vigneaud Award for Young Investigators in Peptide Chemistry
Guggenheim Fellowship
Fellow, American Association for the Advancement of Science
D.Sc. honoris causa, Mount Holyoke College
American Chemical Society Garvan-Olin Award, 2006
NIH Director's Pioneer Award

Lederle Graduate Research Tower 1224
710 North Pleasant Street
University of Massachusetts Amherst
Amherst, MA 01003
Tel: 413-545-6094

FoldEco: A Model for Proteostasis in E. coli

Cell Reports (2012)

Evan T. Powers, David L. Powers and Lila Gierasch

To gain insight into the interplay of processes and species that maintain a correctly folded, functional proteome, we have developed ...

Segmental isotopic labeling of the Hsp70 molecular chaperone DnaK using ...

Biopolymers (2011)

Eugenia M. Clerico, Anastasia Zhuravleva, Robert G. Smock and Lila Gierasch

Introducing biophysical labels into specific regions of large and dynamic multidomain proteins greatly facilitates mechanistic analysis. Ligation of expressed domains ...

An interdomain sector mediating allostery in Hsp70 molecular chaperones

Molecular Systems Biology (2010)

Robert G. Smock, Olivier Rivoire, William P. Russ, Joanna F. Swain, et al.

Allosteric coupling between protein domains is fundamental to many cellular processes. For example, Hsp70 molecular chaperones use ATP binding by ...

Role of Hsp70 ATPase Domain Intrinsic Dynamics and Sequence Evolution ...

PLoS Computational Biology (2010)

Ying Liu, Lila Gierasch and Ivet Bahar

12 Hide Figures Abstract Author Summary Introduction Materials and Methods Results Discussion Supporting Information Acknowledgments Author Contributions References Reader Comments ...

The Structure of Escherichia coli Signal Recognition Particle Revealed by ...

Molecular and Cellular Biology (2006)

Lain L. Mainprize, Daniel R. Beniac, Elena Falkovskaia, Robert M. Cleverley, et al.

Structural studies on various domains of the ribonucleoprotein signal recognition particle (SRP) have not converged on a single complete structure ...

Dependence of Endoplasmic Reticulum-associated Degradation on the Peptide Binding Domain ...

Molecular Biology of the Cell (2003)

Mehdi Kabani, Stephanie S. Kelley, Michael W. Morrow, Diana L. Montgomery, et al.

ER-associated degradation (ERAD) removes defective and mis-folded proteins from the eukaryotic secretory pathway, but mutations in the ER lumenal Hsp70, ...

The LDL receptor clustering motif interacts with the clathrin terminal ...

Journal of Cell Biology (1998)

Richard G. Kibbey, Josep Rizo, Lila Gierasch and Richard G. W. Anderson

Previously the hexapeptide motif FXNPXY807 in the cytoplasmic tail of the LDL receptor was shown to be essential for clustering ...

Effect of charged residue substitutions on the membrane-interactive properties of ...

Biophysical Journal (1994)

Jeffrey D. Jones and Lila Gierasch

Although the central role of the signal sequence in protein export is well established, the molecular details underlying signal sequence ...

Effect of charged residue substitutions on the thermodynamics of signal ...

Biophysical Journal (1994)

Jeffrey D. Jones and Lila Gierasch

We have used tryptophan fluorescence spectroscopy to characterize the binding affinities of an Escherichia coli LamB signal peptide family for ...

Reorganization of lipid domain structure in membranes by a transmembrane ...

Biophysical Journal (1994)

M. B. Sankaram, D. Marsh, Lila Gierasch and T. E. Thompson

The effect of a transmembrane peptide on the domain structure of a two-component, two-phase lipid bilayer composed of dimyristoyl phosphatidylcholine ...

Glossary for Chemists of Terms Used in Biotechnology

Pure and Applied Chemistry (1992)

B. Nagel, H. Dellweg and Lila Gierasch

The glossary contains definitions and explanatory notes, if needed, of over 230 terms frequently used in publications in the multidisciplinary ...